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The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus

OBJECTIVES: To assess a non-invasive means of predicting a venous trans-stenotic pressure gradient (TPG) and intracranial pressure (ICP) as opposed to invasive examinations in unilateral venous pulsatile tinnitus (PT) patients. METHODS: Thirty patients with unilateral venous PT who presented symptom...

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Autores principales: Qiu, Xiaoyu, Zhao, Pengfei, Li, Xiaoshuai, Ding, Heyu, Lv, Han, Zeng, Rong, Wang, Guopeng, Jin, Long, Yang, Zhenghan, Gong, Shusheng, Wang, Zhenchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446348/
https://www.ncbi.nlm.nih.gov/pubmed/34539330
http://dx.doi.org/10.3389/fnins.2021.694731
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author Qiu, Xiaoyu
Zhao, Pengfei
Li, Xiaoshuai
Ding, Heyu
Lv, Han
Zeng, Rong
Wang, Guopeng
Jin, Long
Yang, Zhenghan
Gong, Shusheng
Wang, Zhenchang
author_facet Qiu, Xiaoyu
Zhao, Pengfei
Li, Xiaoshuai
Ding, Heyu
Lv, Han
Zeng, Rong
Wang, Guopeng
Jin, Long
Yang, Zhenghan
Gong, Shusheng
Wang, Zhenchang
author_sort Qiu, Xiaoyu
collection PubMed
description OBJECTIVES: To assess a non-invasive means of predicting a venous trans-stenotic pressure gradient (TPG) and intracranial pressure (ICP) as opposed to invasive examinations in unilateral venous pulsatile tinnitus (PT) patients. METHODS: Thirty patients with unilateral venous PT who presented symptomatic-sided transverse sinus stenosis (TSS) on computed tomography venography (CTV), ipsilateral TPG measured by digital subtraction angiography (DSA) and cerebrospinal fluid (CSF) pressure measured by lumbar puncture were included. The ratio of TSS was calculated by dividing the cross-sectional areas of the maximal stenosed transverse sinus by that of the adjacent normal transverse sinus on CTV. The correlations among and predictive values of TSS, TPG, and ICP were analyzed. RESULTS: In patients with unilateral venous PT, the symptomatic-sided and average bilateral TSS values were 78 ± 11 and 77 ± 9%; ICP, 230.50 ± 55.75 mmH(2)O; and the TPG, 9.51 ± 5.76 mmHg. The symptomatic-sided TSS was linearly and positively correlated with TPG (R(2) = 0.400), and the symptomatic-sided and bilateral average TSS both showed weak correlations with ICP (R(2) = 0.288, R′(2) = 0.156). When the degree of TSS increased by 10%, the TPG and ICP increased by approximately 3.3 mmHg and 25.8 mmH(2)O, respectively. The receiver operating characteristic curve showed the optimal threshold of ipsilateral TSS for a positive TPG was 0.75, while TSS had no significant predictive value for ICP (p > 0.05). TPG and ICP also exhibited a linear positive correlation (R(2) = 0.552). When ICP increased by 10 mmH(2)O, the TPG increased by approximately 0.77 mmHg, and the optimal threshold of ICP for a positive TPG was 227.5. CONCLUSION: TSS, TPG, and ICP are interrelated. TSS measured by CTV can predict TPG in patients with unilateral venous PT.
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spelling pubmed-84463482021-09-18 The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus Qiu, Xiaoyu Zhao, Pengfei Li, Xiaoshuai Ding, Heyu Lv, Han Zeng, Rong Wang, Guopeng Jin, Long Yang, Zhenghan Gong, Shusheng Wang, Zhenchang Front Neurosci Neuroscience OBJECTIVES: To assess a non-invasive means of predicting a venous trans-stenotic pressure gradient (TPG) and intracranial pressure (ICP) as opposed to invasive examinations in unilateral venous pulsatile tinnitus (PT) patients. METHODS: Thirty patients with unilateral venous PT who presented symptomatic-sided transverse sinus stenosis (TSS) on computed tomography venography (CTV), ipsilateral TPG measured by digital subtraction angiography (DSA) and cerebrospinal fluid (CSF) pressure measured by lumbar puncture were included. The ratio of TSS was calculated by dividing the cross-sectional areas of the maximal stenosed transverse sinus by that of the adjacent normal transverse sinus on CTV. The correlations among and predictive values of TSS, TPG, and ICP were analyzed. RESULTS: In patients with unilateral venous PT, the symptomatic-sided and average bilateral TSS values were 78 ± 11 and 77 ± 9%; ICP, 230.50 ± 55.75 mmH(2)O; and the TPG, 9.51 ± 5.76 mmHg. The symptomatic-sided TSS was linearly and positively correlated with TPG (R(2) = 0.400), and the symptomatic-sided and bilateral average TSS both showed weak correlations with ICP (R(2) = 0.288, R′(2) = 0.156). When the degree of TSS increased by 10%, the TPG and ICP increased by approximately 3.3 mmHg and 25.8 mmH(2)O, respectively. The receiver operating characteristic curve showed the optimal threshold of ipsilateral TSS for a positive TPG was 0.75, while TSS had no significant predictive value for ICP (p > 0.05). TPG and ICP also exhibited a linear positive correlation (R(2) = 0.552). When ICP increased by 10 mmH(2)O, the TPG increased by approximately 0.77 mmHg, and the optimal threshold of ICP for a positive TPG was 227.5. CONCLUSION: TSS, TPG, and ICP are interrelated. TSS measured by CTV can predict TPG in patients with unilateral venous PT. Frontiers Media S.A. 2021-09-03 /pmc/articles/PMC8446348/ /pubmed/34539330 http://dx.doi.org/10.3389/fnins.2021.694731 Text en Copyright © 2021 Qiu, Zhao, Li, Ding, Lv, Zeng, Wang, Jin, Yang, Gong and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Qiu, Xiaoyu
Zhao, Pengfei
Li, Xiaoshuai
Ding, Heyu
Lv, Han
Zeng, Rong
Wang, Guopeng
Jin, Long
Yang, Zhenghan
Gong, Shusheng
Wang, Zhenchang
The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title_full The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title_fullStr The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title_full_unstemmed The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title_short The Relationships Among Transverse Sinus Stenosis Measured by CT Venography, Venous Trans-stenotic Pressure Gradient and Intracranial Pressure in Patients With Unilateral Venous Pulsatile Tinnitus
title_sort relationships among transverse sinus stenosis measured by ct venography, venous trans-stenotic pressure gradient and intracranial pressure in patients with unilateral venous pulsatile tinnitus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446348/
https://www.ncbi.nlm.nih.gov/pubmed/34539330
http://dx.doi.org/10.3389/fnins.2021.694731
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