Cargando…
Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study
BACKGROUND: As the incidence of breast cancer has increased and the survival rate has improved, supporting the optimal follow‐up strategy has become an important issue. This study aimed to evaluate follow‐up imaging usage after breast cancer surgery and the implications on mortality in Korea. METHOD...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446413/ https://www.ncbi.nlm.nih.gov/pubmed/34472221 http://dx.doi.org/10.1002/cam4.3873 |
_version_ | 1784568866961096704 |
---|---|
author | Jung, So‐Youn Kim, Young Ae Lee, Dong‐Eun Joo, Jungnam Back, Joung Hwan Kong, Sun‐Young Lee, Eun Sook |
author_facet | Jung, So‐Youn Kim, Young Ae Lee, Dong‐Eun Joo, Jungnam Back, Joung Hwan Kong, Sun‐Young Lee, Eun Sook |
author_sort | Jung, So‐Youn |
collection | PubMed |
description | BACKGROUND: As the incidence of breast cancer has increased and the survival rate has improved, supporting the optimal follow‐up strategy has become an important issue. This study aimed to evaluate follow‐up imaging usage after breast cancer surgery and the implications on mortality in Korea. METHODS: This study included 96,575 breast cancer patients diagnosed during 2002–2010 and registered in the Korea Central Cancer Registry, Statistics Korea, and Korean National Health Insurance Service. We evaluated the frequency of breast imaging (mammography and breast MRI) and systemic imaging for evaluating the presence of distant metastasis (chest CT, bone scan, and PET‐CT), and performed analyses to determine if they had an effect on mortality. RESULTS: The median follow‐up period was 72.9 months (range: 12.0–133.3) and 7.5% of the patients died. Among all patients, 54.7%, 16.2%, 45.6%, and 8.5% received 3 or more mammograms, chest CTs, bone scans, and PET‐CTs within 3 years after surgery, respectively. Among patients who developed recurrence after 3 or more years, a comparison of overall mortality and breast‐cancer specific mortality according to the frequency of imaging by modality (<3 vs. ≥3) showed that only mammography had significantly reduced mortality (hazard ratio [HR]: 0.72, 95% CI: 0.61–0.84, p < 0.0001; HR: 0.72, 95% CI: 0.61–0.84; p < 0.0001). CONCLUSIONS: This study showed that only frequent mammography reduced mortality and frequent imaging follow‐up with other modalities did not when compared to less frequent imaging. This finding provides supportive evidence that clinicians need to adhere to the current guidelines for surveillance after breast cancer surgery. |
format | Online Article Text |
id | pubmed-8446413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84464132021-09-22 Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study Jung, So‐Youn Kim, Young Ae Lee, Dong‐Eun Joo, Jungnam Back, Joung Hwan Kong, Sun‐Young Lee, Eun Sook Cancer Med Cancer Prevention BACKGROUND: As the incidence of breast cancer has increased and the survival rate has improved, supporting the optimal follow‐up strategy has become an important issue. This study aimed to evaluate follow‐up imaging usage after breast cancer surgery and the implications on mortality in Korea. METHODS: This study included 96,575 breast cancer patients diagnosed during 2002–2010 and registered in the Korea Central Cancer Registry, Statistics Korea, and Korean National Health Insurance Service. We evaluated the frequency of breast imaging (mammography and breast MRI) and systemic imaging for evaluating the presence of distant metastasis (chest CT, bone scan, and PET‐CT), and performed analyses to determine if they had an effect on mortality. RESULTS: The median follow‐up period was 72.9 months (range: 12.0–133.3) and 7.5% of the patients died. Among all patients, 54.7%, 16.2%, 45.6%, and 8.5% received 3 or more mammograms, chest CTs, bone scans, and PET‐CTs within 3 years after surgery, respectively. Among patients who developed recurrence after 3 or more years, a comparison of overall mortality and breast‐cancer specific mortality according to the frequency of imaging by modality (<3 vs. ≥3) showed that only mammography had significantly reduced mortality (hazard ratio [HR]: 0.72, 95% CI: 0.61–0.84, p < 0.0001; HR: 0.72, 95% CI: 0.61–0.84; p < 0.0001). CONCLUSIONS: This study showed that only frequent mammography reduced mortality and frequent imaging follow‐up with other modalities did not when compared to less frequent imaging. This finding provides supportive evidence that clinicians need to adhere to the current guidelines for surveillance after breast cancer surgery. John Wiley and Sons Inc. 2021-09-01 /pmc/articles/PMC8446413/ /pubmed/34472221 http://dx.doi.org/10.1002/cam4.3873 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Jung, So‐Youn Kim, Young Ae Lee, Dong‐Eun Joo, Jungnam Back, Joung Hwan Kong, Sun‐Young Lee, Eun Sook Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title | Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title_full | Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title_fullStr | Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title_full_unstemmed | Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title_short | Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study |
title_sort | clinical impact of follow‐up imaging on mortality in korean breast cancer patients: a national cohort study |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446413/ https://www.ncbi.nlm.nih.gov/pubmed/34472221 http://dx.doi.org/10.1002/cam4.3873 |
work_keys_str_mv | AT jungsoyoun clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT kimyoungae clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT leedongeun clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT joojungnam clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT backjounghwan clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT kongsunyoung clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy AT leeeunsook clinicalimpactoffollowupimagingonmortalityinkoreanbreastcancerpatientsanationalcohortstudy |