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Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis

Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symp...

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Autores principales: Deana, Cristian, Vetrugno, Luigi, Fabris, Martina, Curcio, Francesco, Sozio, Emanuela, Tascini, Carlo, Bassi, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446479/
https://www.ncbi.nlm.nih.gov/pubmed/34533672
http://dx.doi.org/10.1007/s10753-021-01563-3
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author Deana, Cristian
Vetrugno, Luigi
Fabris, Martina
Curcio, Francesco
Sozio, Emanuela
Tascini, Carlo
Bassi, Flavio
author_facet Deana, Cristian
Vetrugno, Luigi
Fabris, Martina
Curcio, Francesco
Sozio, Emanuela
Tascini, Carlo
Bassi, Flavio
author_sort Deana, Cristian
collection PubMed
description Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symptoms are the most frequently reported manifestation of the disease. Indeed, cardiac involvement is reported mostly as a part of a systemic disease. Few isolated cardiac manifestations of COVID-19 infection have been described. We report herein a case of SARS-CoV-2 related severe isolated pericardial involvement requiring ICU admission due to cardiac tamponade needing urgent drainage. Analysis of pericardial fluid from drainage demonstrated a higher cytokine concentration than blood values. Other causes of pericardial disease, such as autoimmunity, bacterial or other than COVID-19 infection, neoplasms or acute myocardial infarction were also evaluated, but all tests confirmed negative results. The suspicion of isolated involvement of the pericardium was therefore demonstrated by the analysis of cytokines which strongly support our hypothesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10753-021-01563-3.
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spelling pubmed-84464792021-09-17 Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis Deana, Cristian Vetrugno, Luigi Fabris, Martina Curcio, Francesco Sozio, Emanuela Tascini, Carlo Bassi, Flavio Inflammation Letter to the Editor Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symptoms are the most frequently reported manifestation of the disease. Indeed, cardiac involvement is reported mostly as a part of a systemic disease. Few isolated cardiac manifestations of COVID-19 infection have been described. We report herein a case of SARS-CoV-2 related severe isolated pericardial involvement requiring ICU admission due to cardiac tamponade needing urgent drainage. Analysis of pericardial fluid from drainage demonstrated a higher cytokine concentration than blood values. Other causes of pericardial disease, such as autoimmunity, bacterial or other than COVID-19 infection, neoplasms or acute myocardial infarction were also evaluated, but all tests confirmed negative results. The suspicion of isolated involvement of the pericardium was therefore demonstrated by the analysis of cytokines which strongly support our hypothesis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10753-021-01563-3. Springer US 2021-09-17 2022 /pmc/articles/PMC8446479/ /pubmed/34533672 http://dx.doi.org/10.1007/s10753-021-01563-3 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Letter to the Editor
Deana, Cristian
Vetrugno, Luigi
Fabris, Martina
Curcio, Francesco
Sozio, Emanuela
Tascini, Carlo
Bassi, Flavio
Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title_full Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title_fullStr Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title_full_unstemmed Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title_short Pericardial Cytokine “Storm” in a COVID-19 Patient: the Confirmation of a Hypothesis
title_sort pericardial cytokine “storm” in a covid-19 patient: the confirmation of a hypothesis
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446479/
https://www.ncbi.nlm.nih.gov/pubmed/34533672
http://dx.doi.org/10.1007/s10753-021-01563-3
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