Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings ind...

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Detalles Bibliográficos
Autores principales: Xia, Yujia, Brown, Zachary J., Huang, Hai, Tsung, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446566/
https://www.ncbi.nlm.nih.gov/pubmed/34390203
http://dx.doi.org/10.1002/cam4.4177
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author Xia, Yujia
Brown, Zachary J.
Huang, Hai
Tsung, Allan
author_facet Xia, Yujia
Brown, Zachary J.
Huang, Hai
Tsung, Allan
author_sort Xia, Yujia
collection PubMed
description Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.
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spelling pubmed-84465662021-09-22 Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma Xia, Yujia Brown, Zachary J. Huang, Hai Tsung, Allan Cancer Med Cancer Biology Hepatocellular carcinoma (HCC) is a typical inflammation‐induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro‐ and anti‐tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression. John Wiley and Sons Inc. 2021-08-13 /pmc/articles/PMC8446566/ /pubmed/34390203 http://dx.doi.org/10.1002/cam4.4177 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Xia, Yujia
Brown, Zachary J.
Huang, Hai
Tsung, Allan
Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_full Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_fullStr Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_full_unstemmed Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_short Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma
title_sort metabolic reprogramming of immune cells: shaping the tumor microenvironment in hepatocellular carcinoma
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446566/
https://www.ncbi.nlm.nih.gov/pubmed/34390203
http://dx.doi.org/10.1002/cam4.4177
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AT brownzacharyj metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma
AT huanghai metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma
AT tsungallan metabolicreprogrammingofimmunecellsshapingthetumormicroenvironmentinhepatocellularcarcinoma

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