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Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease

Background: The value of aspirin for primary prevention continues to be debated. Data showing whether aspirin use for primary prevention adheres to established guidelines in real world practice are sparse. Methods: A total of 13,104 patients without cardiovascular diseases (CVD) were selected from t...

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Autores principales: Chen, Yinong, Yin, Chun, Li, Qing, Yu, Luyao, Zhu, Longyang, Hu, Dayi, Sun, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446611/
https://www.ncbi.nlm.nih.gov/pubmed/34540919
http://dx.doi.org/10.3389/fcvm.2021.720113
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author Chen, Yinong
Yin, Chun
Li, Qing
Yu, Luyao
Zhu, Longyang
Hu, Dayi
Sun, Yihong
author_facet Chen, Yinong
Yin, Chun
Li, Qing
Yu, Luyao
Zhu, Longyang
Hu, Dayi
Sun, Yihong
author_sort Chen, Yinong
collection PubMed
description Background: The value of aspirin for primary prevention continues to be debated. Data showing whether aspirin use for primary prevention adheres to established guidelines in real world practice are sparse. Methods: A total of 13,104 patients without cardiovascular diseases (CVD) were selected from the DYS-lipidemia International Study of China, a national survey of patients with dyslipidemia in 2012. The CVD risk of the participants were calculated using the 10-year risk of Ischemic Cardiovascular Diseases model. The misuse of aspirin for primary prevention was defined as having CVD risk <10% with daily aspirin. Multivariate logistic regression models were used to explore risk factors associated with aspirin misuse. Results: The proportion of the patients categorized as low, moderate and high risk for CVD were 52.9, 21.6, and 25.4% respectively. The misuse frequency of aspirin was 31.0% (2,147/6,933) in patients with low risk. The misuse of aspirin increased with aging for both men and women. In the multivariate analysis, the independent risk factors associated with aspirin misuse were hypertension, diabetes mellitus, a family history of premature CVD, and elderly age. Level of total cholesterol is negatively associated with aspirin misuse. Patients from low level hospitals are more likely to be taking aspirin inappropriately. Results remained consistent after including 2,837 patients having 10-year risk for CVD between 10 and <20%. Conclusion: The misuse of aspirin for primary prevention is common in patients having CVD risk <10%. There are important opportunities to improve evidence-based aspirin use for the primary prevention of CVD in Chinese patients. Clinical Trial Registration:https://clinicaltrials.gov/, identifier [NCT01732952].
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spelling pubmed-84466112021-09-18 Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease Chen, Yinong Yin, Chun Li, Qing Yu, Luyao Zhu, Longyang Hu, Dayi Sun, Yihong Front Cardiovasc Med Cardiovascular Medicine Background: The value of aspirin for primary prevention continues to be debated. Data showing whether aspirin use for primary prevention adheres to established guidelines in real world practice are sparse. Methods: A total of 13,104 patients without cardiovascular diseases (CVD) were selected from the DYS-lipidemia International Study of China, a national survey of patients with dyslipidemia in 2012. The CVD risk of the participants were calculated using the 10-year risk of Ischemic Cardiovascular Diseases model. The misuse of aspirin for primary prevention was defined as having CVD risk <10% with daily aspirin. Multivariate logistic regression models were used to explore risk factors associated with aspirin misuse. Results: The proportion of the patients categorized as low, moderate and high risk for CVD were 52.9, 21.6, and 25.4% respectively. The misuse frequency of aspirin was 31.0% (2,147/6,933) in patients with low risk. The misuse of aspirin increased with aging for both men and women. In the multivariate analysis, the independent risk factors associated with aspirin misuse were hypertension, diabetes mellitus, a family history of premature CVD, and elderly age. Level of total cholesterol is negatively associated with aspirin misuse. Patients from low level hospitals are more likely to be taking aspirin inappropriately. Results remained consistent after including 2,837 patients having 10-year risk for CVD between 10 and <20%. Conclusion: The misuse of aspirin for primary prevention is common in patients having CVD risk <10%. There are important opportunities to improve evidence-based aspirin use for the primary prevention of CVD in Chinese patients. Clinical Trial Registration:https://clinicaltrials.gov/, identifier [NCT01732952]. Frontiers Media S.A. 2021-09-03 /pmc/articles/PMC8446611/ /pubmed/34540919 http://dx.doi.org/10.3389/fcvm.2021.720113 Text en Copyright © 2021 Chen, Yin, Li, Yu, Zhu, Hu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Chen, Yinong
Yin, Chun
Li, Qing
Yu, Luyao
Zhu, Longyang
Hu, Dayi
Sun, Yihong
Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title_full Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title_fullStr Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title_full_unstemmed Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title_short Misuse of Aspirin and Associated Factors for the Primary Prevention of Cardiovascular Disease
title_sort misuse of aspirin and associated factors for the primary prevention of cardiovascular disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446611/
https://www.ncbi.nlm.nih.gov/pubmed/34540919
http://dx.doi.org/10.3389/fcvm.2021.720113
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