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The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease

A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in th...

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Autores principales: Stonebarger, Gail A., Bimonte-Nelson, Heather A., Urbanski, Henryk F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446616/
https://www.ncbi.nlm.nih.gov/pubmed/34539388
http://dx.doi.org/10.3389/fnagi.2021.734173
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author Stonebarger, Gail A.
Bimonte-Nelson, Heather A.
Urbanski, Henryk F.
author_facet Stonebarger, Gail A.
Bimonte-Nelson, Heather A.
Urbanski, Henryk F.
author_sort Stonebarger, Gail A.
collection PubMed
description A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in the context of Alzheimer’s disease (AD). Additionally, it will examine the use of the rhesus macaque monkey as a pragmatic translational animal model in which to study underlying causal mechanisms. Specifically, the discussion will focus on behavioral and protein-level brain changes that occur within the central nervous system (CNS) of aged monkeys, and compare them to the changes observed in humans during clinically normative aging and in AD.
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spelling pubmed-84466162021-09-18 The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease Stonebarger, Gail A. Bimonte-Nelson, Heather A. Urbanski, Henryk F. Front Aging Neurosci Aging Neuroscience A major obstacle to progress in understanding the etiology of normative and pathological human brain aging is the availability of suitable animal models for experimentation. The present article will highlight our current knowledge regarding human brain aging and neurodegeneration, specifically in the context of Alzheimer’s disease (AD). Additionally, it will examine the use of the rhesus macaque monkey as a pragmatic translational animal model in which to study underlying causal mechanisms. Specifically, the discussion will focus on behavioral and protein-level brain changes that occur within the central nervous system (CNS) of aged monkeys, and compare them to the changes observed in humans during clinically normative aging and in AD. Frontiers Media S.A. 2021-09-03 /pmc/articles/PMC8446616/ /pubmed/34539388 http://dx.doi.org/10.3389/fnagi.2021.734173 Text en Copyright © 2021 Stonebarger, Bimonte-Nelson and Urbanski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Stonebarger, Gail A.
Bimonte-Nelson, Heather A.
Urbanski, Henryk F.
The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title_full The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title_fullStr The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title_full_unstemmed The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title_short The Rhesus Macaque as a Translational Model for Neurodegeneration and Alzheimer’s Disease
title_sort rhesus macaque as a translational model for neurodegeneration and alzheimer’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446616/
https://www.ncbi.nlm.nih.gov/pubmed/34539388
http://dx.doi.org/10.3389/fnagi.2021.734173
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