The Effect of Local Renin Angiotensin System in the Common Types of Cancer

The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body’s tissues. In this review, current knowledge on the effect of local RAS in...

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Autores principales: Almutlaq, Moudhi, Alamro, Abir Abdullah, Alamri, Hassan S., Alghamdi, Amani Ahmed, Barhoumi, Tlili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446618/
https://www.ncbi.nlm.nih.gov/pubmed/34539580
http://dx.doi.org/10.3389/fendo.2021.736361
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author Almutlaq, Moudhi
Alamro, Abir Abdullah
Alamri, Hassan S.
Alghamdi, Amani Ahmed
Barhoumi, Tlili
author_facet Almutlaq, Moudhi
Alamro, Abir Abdullah
Alamri, Hassan S.
Alghamdi, Amani Ahmed
Barhoumi, Tlili
author_sort Almutlaq, Moudhi
collection PubMed
description The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body’s tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.
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spelling pubmed-84466182021-09-18 The Effect of Local Renin Angiotensin System in the Common Types of Cancer Almutlaq, Moudhi Alamro, Abir Abdullah Alamri, Hassan S. Alghamdi, Amani Ahmed Barhoumi, Tlili Front Endocrinol (Lausanne) Endocrinology The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body’s tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer. Frontiers Media S.A. 2021-09-03 /pmc/articles/PMC8446618/ /pubmed/34539580 http://dx.doi.org/10.3389/fendo.2021.736361 Text en Copyright © 2021 Almutlaq, Alamro, Alamri, Alghamdi and Barhoumi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Almutlaq, Moudhi
Alamro, Abir Abdullah
Alamri, Hassan S.
Alghamdi, Amani Ahmed
Barhoumi, Tlili
The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title_full The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title_fullStr The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title_full_unstemmed The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title_short The Effect of Local Renin Angiotensin System in the Common Types of Cancer
title_sort effect of local renin angiotensin system in the common types of cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446618/
https://www.ncbi.nlm.nih.gov/pubmed/34539580
http://dx.doi.org/10.3389/fendo.2021.736361
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