Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells

CD38 is the major NAD(+)-hydrolyzing ecto-enzyme in most mammals. As a type II transmembrane protein, CD38 is also a promising target for the immunotherapy of multiple myeloma (MM). Nanobodies are single immunoglobulin variable domains from heavy chain antibodies that naturally occur in camelids. Us...

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Detalles Bibliográficos
Autores principales: Baum, Natalie, Eggers, Marie, Koenigsdorf, Julia, Menzel, Stephan, Hambach, Julia, Staehler, Tobias, Fliegert, Ralf, Kulow, Frederike, Adam, Gerhard, Haag, Friedrich, Bannas, Peter, Koch-Nolte, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446682/
https://www.ncbi.nlm.nih.gov/pubmed/34539634
http://dx.doi.org/10.3389/fimmu.2021.703574

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