Cargando…

Emerging therapeutic opportunities for integrin inhibitors

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel disease/multiple sclerosis and dry eye disease, respectiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Slack, R. J., Macdonald, S. J. F., Roper, J. A., Jenkins, R. G., Hatley, R. J. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446727/ https://www.ncbi.nlm.nih.gov/pubmed/34535788 http://dx.doi.org/10.1038/s41573-021-00284-4

Ejemplares similares

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
por: Li, Siyi, et al.
Publicado: (2023)

Lipogenesis inhibitors: therapeutic opportunities and challenges
por: Batchuluun, Battsetseg, et al.
Publicado: (2022)

Integrin Inhibitors as a Therapeutic Agent for Ovarian Cancer
por: Sawada, Kenjiro, et al.
Publicado: (2012)

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
por: John, Alison E., et al.
Publicado: (2020)

Integrins regulate stemness in solid tumor: an emerging therapeutic target
por: Xiong, Jiangling, et al.
Publicado: (2021)

Ferroptosis: An emerging therapeutic opportunity for cancer
por: Wang, Liyuan, et al.
Publicado: (2020)

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities
por: Bergonzini, Cecilia, et al.
Publicado: (2022)

Integrin Targeted Therapeutics
por: Millard, Melissa, et al.
Publicado: (2011)

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors
por: Prescott, Jack A., et al.
Publicado: (2018)

Integrins as Therapeutic Targets: Successes and Cancers
por: Raab-Westphal, Sabine, et al.
Publicado: (2017)

PARP Inhibitors in Glioma: A Review of Therapeutic Opportunities
por: Sim, Hao-Wen, et al.
Publicado: (2022)

Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders
por: Pinho, Andreia G., et al.
Publicado: (2020)

Integrin Inhibitors in Prostate Cancer
por: Juan-Rivera, Maylein C., et al.
Publicado: (2018)

Emerging roles of lncRNA in Nasopharyngeal Carcinoma and therapeutic opportunities
por: Wang, Haihua, et al.
Publicado: (2022)

Lysine Acetylation, Cancer Hallmarks and Emerging Onco-Therapeutic Opportunities
por: Hu, Meilan, et al.
Publicado: (2022)

Regulation of Metastatic Tumor Dormancy and Emerging Opportunities for Therapeutic Intervention
por: Tamamouna, Vasilia, et al.
Publicado: (2022)

New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology
por: Roulston, Anne, et al.
Publicado: (2015)

Integrins as attractive targets for cancer therapeutics
por: Li, Meng, et al.
Publicado: (2021)

Integrin Targeted Delivery of Gene Therapeutics
por: Juliano, Rudy L, et al.
Publicado: (2011)

Evaluation of α(2)-Integrin Expression as a Biomarker for Tumor Growth Inhibition for the Investigational Integrin Inhibitor E7820 in Preclinical and Clinical Studies
por: Keizer, Ron J., et al.
Publicado: (2011)

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities
por: Seropian, Ignacio M., et al.
Publicado: (2018)

ADAM17: An Emerging Therapeutic Target for Lung Cancer
por: Saad, Mohamed I., et al.
Publicado: (2019)

The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis
por: Zhang, Fengrui, et al.
Publicado: (2023)

Syndecan and integrin interactomes: large complexes in small spaces
por: Roper, James A, et al.
Publicado: (2012)

Mitochondrial Base Editing: Recent Advances towards Therapeutic Opportunities
por: Kar, Bibekananda, et al.
Publicado: (2023)

Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology
por: Vivet-Noguer, Raquel, et al.
Publicado: (2019)

Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
por: Zhou, Chuchao, et al.
Publicado: (2023)

X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging
por: O'Sullivan, James D. B., et al.
Publicado: (2018)

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
por: Hammond, Suzan M, et al.
Publicado: (2021)

New Opportunities in Glycan Engineering for Therapeutic Proteins
por: Zhong, Xiaotian, et al.
Publicado: (2022)

Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors
por: Ulke-Lemée, Annegret, et al.
Publicado: (2010)

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
por: McCubrey, J A, et al.
Publicado: (2014)

Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine
por: Singh, Manish Pratap, et al.
Publicado: (2019)

Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
por: Prattichizzo, F., et al.
Publicado: (2016)

Integrin Signaling Shaping BTK-Inhibitor Resistance
por: Polcik, Laura, et al.
Publicado: (2022)

Emerging Opportunities for Serotypes of Botulinum Neurotoxins
por: Peng Chen, Zhongxing, et al.
Publicado: (2012)

Synthetic lethality: emerging targets and opportunities in melanoma
por: Thompson, Nicola, et al.
Publicado: (2017)

Metalloproteinases and their inhibitors—diagnostic and therapeutic opportunities in orthopedics
por: Pasternak, Björn, et al.
Publicado: (2009)

Spotlight on New Therapeutic Opportunities for MYC-Driven Cancers
por: D’Avola, Annalisa, et al.
Publicado: (2023)

Emergence of TNIK inhibitors in cancer therapeutics
por: Yamada, Tesshi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e51o8jultj6kh38q6lcvmcljub