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The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene

GGGGCC (G(4)C(2)) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide repeat proteins produced through repeat-associated non-AUG (RAN) translation are recognized as potential drivers for neurodegeneration. Theref...

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Detalles Bibliográficos
Autores principales:	Mori, Kohji, Gotoh, Shiho, Yamashita, Tomoko, Uozumi, Ryota, Kawabe, Yuya, Tagami, Shinji, Kamp, Frits, Nuscher, Brigitte, Edbauer, Dieter, Haass, Christian, Nagai, Yoshitaka, Ikeda, Manabu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446798/ https://www.ncbi.nlm.nih.gov/pubmed/34450161 http://dx.doi.org/10.1016/j.jbc.2021.101120

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