Bystander CD4 T-cell death is inhibited by broadly neutralizing anti-HIV antibodies only at levels blocking cell-to-cell viral transmission

The progressive loss of CD4+ T cells during HIV infection of lymphoid tissues involves both the apoptotic death of activated and productively infected CD4 T cells and the pyroptotic death of large numbers of resting and abortively infected bystander CD4 T cells. HIV spreads both through cellular rel...

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Detalles Bibliográficos
Autores principales: Luo, Xiaoyu, Mouquet, Hugo, Schwartz, Olivier, Greene, Warner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446805/
https://www.ncbi.nlm.nih.gov/pubmed/34418431
http://dx.doi.org/10.1016/j.jbc.2021.101098

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