A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist

Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unp...

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Autores principales: Shah, Amar S., Civelli, Valerie F., Bali, Varun, Johnson, Royce H., Heidari, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447092/
https://www.ncbi.nlm.nih.gov/pubmed/34521227
http://dx.doi.org/10.1177/23247096211045450
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author Shah, Amar S.
Civelli, Valerie F.
Bali, Varun
Johnson, Royce H.
Heidari, Arash
author_facet Shah, Amar S.
Civelli, Valerie F.
Bali, Varun
Johnson, Royce H.
Heidari, Arash
author_sort Shah, Amar S.
collection PubMed
description Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unpredictable pathobiologic, clinical, and transmittable implications. Standard laboratory testing for genomic HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains challenging. Herein is a case of s-variant chronic HBV infection in a 55-year-old man. Diagnosis and treatment are described.
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spelling pubmed-84470922021-09-18 A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist Shah, Amar S. Civelli, Valerie F. Bali, Varun Johnson, Royce H. Heidari, Arash J Investig Med High Impact Case Rep Case Report Genomic variants of the hepatitis B virus (HBV) preS/S protein are well-known to occur. Typically, immunity is gained through recovered HBV infection or by immunization. Very rarely, there are certain mutations that may enable HBV escape from the immune detection. PreS/S mutants may present with unpredictable pathobiologic, clinical, and transmittable implications. Standard laboratory testing for genomic HBV variants is not routinely performed by reference guidelines. s-variant HBV management remains challenging. Herein is a case of s-variant chronic HBV infection in a 55-year-old man. Diagnosis and treatment are described. SAGE Publications 2021-09-14 /pmc/articles/PMC8447092/ /pubmed/34521227 http://dx.doi.org/10.1177/23247096211045450 Text en © 2021 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Shah, Amar S.
Civelli, Valerie F.
Bali, Varun
Johnson, Royce H.
Heidari, Arash
A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title_full A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title_fullStr A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title_full_unstemmed A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title_short A Case of S-Variant Hepatitis B Virus: An Immune System Escape Artist
title_sort case of s-variant hepatitis b virus: an immune system escape artist
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447092/
https://www.ncbi.nlm.nih.gov/pubmed/34521227
http://dx.doi.org/10.1177/23247096211045450
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