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Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic

Whether people living with HIV (PLWH) are at greater risk of acquiring SARS‐CoV‐2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and...

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Autores principales: Fernandez‐Fuertes, Marta, Corma‐Gomez, Anaïs, Torres, Eva, Rodriguez‐Pineda, Elena, Fuentes‐Lopez, Ana, Rincon, Pilar, Fernandez, Nieves, Garcia, Federico, Bernal, Samuel, Real, Luis M., Macias, Juan, Pineda, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447136/
https://www.ncbi.nlm.nih.gov/pubmed/34405560
http://dx.doi.org/10.1111/tbed.14293
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author Fernandez‐Fuertes, Marta
Corma‐Gomez, Anaïs
Torres, Eva
Rodriguez‐Pineda, Elena
Fuentes‐Lopez, Ana
Rincon, Pilar
Fernandez, Nieves
Garcia, Federico
Bernal, Samuel
Real, Luis M.
Macias, Juan
Pineda, Juan A.
author_facet Fernandez‐Fuertes, Marta
Corma‐Gomez, Anaïs
Torres, Eva
Rodriguez‐Pineda, Elena
Fuentes‐Lopez, Ana
Rincon, Pilar
Fernandez, Nieves
Garcia, Federico
Bernal, Samuel
Real, Luis M.
Macias, Juan
Pineda, Juan A.
author_sort Fernandez‐Fuertes, Marta
collection PubMed
description Whether people living with HIV (PLWH) are at greater risk of acquiring SARS‐CoV‐2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS‐CoV‐2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS‐CoV‐2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%–9.9%] patients developed SARS‐CoV‐2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%–9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%–2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS‐Cov‐2 infection [Incidence rate ratio: 0.29 (95% CI 0.16–0.55) p < .001]. In conclusion, the incidence of SARS‐CoV‐2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area.
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spelling pubmed-84471362021-09-17 Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic Fernandez‐Fuertes, Marta Corma‐Gomez, Anaïs Torres, Eva Rodriguez‐Pineda, Elena Fuentes‐Lopez, Ana Rincon, Pilar Fernandez, Nieves Garcia, Federico Bernal, Samuel Real, Luis M. Macias, Juan Pineda, Juan A. Transbound Emerg Dis Original Articles Whether people living with HIV (PLWH) are at greater risk of acquiring SARS‐CoV‐2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS‐CoV‐2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS‐CoV‐2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%–9.9%] patients developed SARS‐CoV‐2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%–9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%–2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS‐Cov‐2 infection [Incidence rate ratio: 0.29 (95% CI 0.16–0.55) p < .001]. In conclusion, the incidence of SARS‐CoV‐2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area. John Wiley and Sons Inc. 2021-09-04 2022-07 /pmc/articles/PMC8447136/ /pubmed/34405560 http://dx.doi.org/10.1111/tbed.14293 Text en © 2021 The Authors. Transboundary and Emerging Diseases published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Fernandez‐Fuertes, Marta
Corma‐Gomez, Anaïs
Torres, Eva
Rodriguez‐Pineda, Elena
Fuentes‐Lopez, Ana
Rincon, Pilar
Fernandez, Nieves
Garcia, Federico
Bernal, Samuel
Real, Luis M.
Macias, Juan
Pineda, Juan A.
Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title_full Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title_fullStr Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title_full_unstemmed Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title_short Incidence of and factors associated with SARS‐CoV‐2 infection among people living with HIV in Southern Spain after one year of pandemic
title_sort incidence of and factors associated with sars‐cov‐2 infection among people living with hiv in southern spain after one year of pandemic
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447136/
https://www.ncbi.nlm.nih.gov/pubmed/34405560
http://dx.doi.org/10.1111/tbed.14293
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