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Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) targets the respiratory and gastric epithelium, causing coronavirus disease 2019 (COVID‐19). Tissue antigen expression variations influence host susceptibility to many infections. This study aimed to investigate the closely lin...

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Autores principales: Matzhold, Eva Maria, Berghold, Andrea, Bemelmans, Maria Karin Berta, Banfi, Chiara, Stelzl, Evelyn, Kessler, Harald Hans, Steinmetz, Ivo, Krause, Robert, Wurzer, Herbert, Schlenke, Peter, Wagner, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447157/
https://www.ncbi.nlm.nih.gov/pubmed/34151460
http://dx.doi.org/10.1111/trf.16567
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author Matzhold, Eva Maria
Berghold, Andrea
Bemelmans, Maria Karin Berta
Banfi, Chiara
Stelzl, Evelyn
Kessler, Harald Hans
Steinmetz, Ivo
Krause, Robert
Wurzer, Herbert
Schlenke, Peter
Wagner, Thomas
author_facet Matzhold, Eva Maria
Berghold, Andrea
Bemelmans, Maria Karin Berta
Banfi, Chiara
Stelzl, Evelyn
Kessler, Harald Hans
Steinmetz, Ivo
Krause, Robert
Wurzer, Herbert
Schlenke, Peter
Wagner, Thomas
author_sort Matzhold, Eva Maria
collection PubMed
description BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) targets the respiratory and gastric epithelium, causing coronavirus disease 2019 (COVID‐19). Tissue antigen expression variations influence host susceptibility to many infections. This study aimed to investigate the closely linked Lewis (FUT3) and ABO histo‐blood types, including secretor (FUT2) status, to infections with SARS‐CoV‐2 and the corresponding severity of COVID‐19. STUDY DESIGN AND METHODS: Patients (Caucasians, n = 338) were genotyped for ABO, FUT3, and FUT2, and compared to a reference population of blood donors (n = 250,298). The association between blood types and severity of COVID‐19 was addressed by dividing patients into four categories: hospitalized individuals in general wards, patients admitted to the intensive care unit with and without intubation, and deceased patients. Comorbidities were considered in subsequent analyses. RESULTS: Patients with blood type Lewis (a−b−) or O were significantly less likely to be hospitalized (odds ratio [OR] 0.669, confidence interval [CI] 0.446–0.971, OR 0.710, CI 0.556–0.900, respectively), while type AB was significantly more prevalent in the patient cohort (OR 1.519, CI 1.014–2.203). The proportions of secretors/nonsecretors, and Lewis a+ or Lewis b+ types were consistent between patients and controls. The analyzed blood groups were not associated with the clinical outcome as defined. DISCUSSION: Blood types Lewis (a−b−) and O were found to be protective factors, whereas the group AB is suggested to be a risk factor for COVID‐19. The antigens investigated may not be prognostic for disease severity, but a role for ABO isoagglutinins in SARS‐CoV‐2 infections is strongly suggested.
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spelling pubmed-84471572021-09-17 Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2 Matzhold, Eva Maria Berghold, Andrea Bemelmans, Maria Karin Berta Banfi, Chiara Stelzl, Evelyn Kessler, Harald Hans Steinmetz, Ivo Krause, Robert Wurzer, Herbert Schlenke, Peter Wagner, Thomas Transfusion Immunohematology BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) targets the respiratory and gastric epithelium, causing coronavirus disease 2019 (COVID‐19). Tissue antigen expression variations influence host susceptibility to many infections. This study aimed to investigate the closely linked Lewis (FUT3) and ABO histo‐blood types, including secretor (FUT2) status, to infections with SARS‐CoV‐2 and the corresponding severity of COVID‐19. STUDY DESIGN AND METHODS: Patients (Caucasians, n = 338) were genotyped for ABO, FUT3, and FUT2, and compared to a reference population of blood donors (n = 250,298). The association between blood types and severity of COVID‐19 was addressed by dividing patients into four categories: hospitalized individuals in general wards, patients admitted to the intensive care unit with and without intubation, and deceased patients. Comorbidities were considered in subsequent analyses. RESULTS: Patients with blood type Lewis (a−b−) or O were significantly less likely to be hospitalized (odds ratio [OR] 0.669, confidence interval [CI] 0.446–0.971, OR 0.710, CI 0.556–0.900, respectively), while type AB was significantly more prevalent in the patient cohort (OR 1.519, CI 1.014–2.203). The proportions of secretors/nonsecretors, and Lewis a+ or Lewis b+ types were consistent between patients and controls. The analyzed blood groups were not associated with the clinical outcome as defined. DISCUSSION: Blood types Lewis (a−b−) and O were found to be protective factors, whereas the group AB is suggested to be a risk factor for COVID‐19. The antigens investigated may not be prognostic for disease severity, but a role for ABO isoagglutinins in SARS‐CoV‐2 infections is strongly suggested. John Wiley & Sons, Inc. 2021-06-26 2021-09 /pmc/articles/PMC8447157/ /pubmed/34151460 http://dx.doi.org/10.1111/trf.16567 Text en © 2021 The Authors. Transfusion published by Wiley Periodicals LLC. on behalf of AABB. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Immunohematology
Matzhold, Eva Maria
Berghold, Andrea
Bemelmans, Maria Karin Berta
Banfi, Chiara
Stelzl, Evelyn
Kessler, Harald Hans
Steinmetz, Ivo
Krause, Robert
Wurzer, Herbert
Schlenke, Peter
Wagner, Thomas
Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title_full Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title_fullStr Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title_full_unstemmed Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title_short Lewis and ABO histo‐blood types and the secretor status of patients hospitalized with COVID‐19 implicate a role for ABO antibodies in susceptibility to infection with SARS‐CoV‐2
title_sort lewis and abo histo‐blood types and the secretor status of patients hospitalized with covid‐19 implicate a role for abo antibodies in susceptibility to infection with sars‐cov‐2
topic Immunohematology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447157/
https://www.ncbi.nlm.nih.gov/pubmed/34151460
http://dx.doi.org/10.1111/trf.16567
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