Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age

Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C is frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkinson’s disease and Alzheimer’s disease. Many studie...

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Detalles Bibliográficos
Autores principales: McGarry, Niamh, Murray, Carol L., Garvey, Sean, Wilkinson, Abigail, Tortorelli, Lucas, Ryan, Lucy, Hayden, Lorna, Healy, Daire, Griffin, Eadaoin W., Hennessy, Edel, Arumugam, Malathy, Skelly, Donal T., Mitchell, Kevin J., Cunningham, Colm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447494/
https://www.ncbi.nlm.nih.gov/pubmed/33892139
http://dx.doi.org/10.1016/j.bbi.2021.04.016

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