A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples

Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and d...

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Detalles Bibliográficos
Autores principales: Zannoli, Silvia, Dirani, Giorgio, Taddei, Francesca, Gatti, Giulia, Poggianti, Ilaria, Denicolò, Agnese, Arfilli, Valentina, Manera, Martina, Mancini, Andrea, Battisti, Arianna, Sambri, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447549/
https://www.ncbi.nlm.nih.gov/pubmed/34649189
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115540
Descripción
Sumario:Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance.

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