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Anti-infective dyes in the time of COVID
The phenomenal global upheaval caused by SARS-CoV-2 has produced amazing responses from science and healthcare, particularly in the rapid realisation and production of vaccines. However, until early 2020 global infection control research was highly focused on rapidly increasing rates of conventional...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier Ltd.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447552/ https://www.ncbi.nlm.nih.gov/pubmed/34548711 http://dx.doi.org/10.1016/j.dyepig.2021.109813 |
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author | Wainwright, Mark |
author_facet | Wainwright, Mark |
author_sort | Wainwright, Mark |
collection | PubMed |
description | The phenomenal global upheaval caused by SARS-CoV-2 has produced amazing responses from science and healthcare, particularly in the rapid realisation and production of vaccines. However, until early 2020 global infection control research was highly focused on rapidly increasing rates of conventional antimicrobial resistance (AMR) and the supply of drugs to counter this. Antimicrobial dyes have been suggested by various authors for inclusion in this effort, usually with little return from responsible authorities, and normally on the basis of post-treatment staining or potential toxicity, but this does not deny the fact that such dyes, particularly with photoactivation, are the only class of agents with pan-microbial activity – i.e. against each of bacteria, viruses, fungi and protozoa – regardless of the organism's drug resistance status. Conventional antibacterials, antivirals etc. usually demonstrate activity against one particular section of pathogens only, and disinfectants such as chlorhexidine or benzalkonium salts are too toxic for internal use. This perspective reflects both the background utility of antimicrobial dyes and ways forward for their inclusion in 21st Century infection control protocols. |
format | Online Article Text |
id | pubmed-8447552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84475522021-09-17 Anti-infective dyes in the time of COVID Wainwright, Mark Dyes Pigm Article The phenomenal global upheaval caused by SARS-CoV-2 has produced amazing responses from science and healthcare, particularly in the rapid realisation and production of vaccines. However, until early 2020 global infection control research was highly focused on rapidly increasing rates of conventional antimicrobial resistance (AMR) and the supply of drugs to counter this. Antimicrobial dyes have been suggested by various authors for inclusion in this effort, usually with little return from responsible authorities, and normally on the basis of post-treatment staining or potential toxicity, but this does not deny the fact that such dyes, particularly with photoactivation, are the only class of agents with pan-microbial activity – i.e. against each of bacteria, viruses, fungi and protozoa – regardless of the organism's drug resistance status. Conventional antibacterials, antivirals etc. usually demonstrate activity against one particular section of pathogens only, and disinfectants such as chlorhexidine or benzalkonium salts are too toxic for internal use. This perspective reflects both the background utility of antimicrobial dyes and ways forward for their inclusion in 21st Century infection control protocols. Elsevier Ltd. 2021-12 2021-09-17 /pmc/articles/PMC8447552/ /pubmed/34548711 http://dx.doi.org/10.1016/j.dyepig.2021.109813 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Wainwright, Mark Anti-infective dyes in the time of COVID |
title | Anti-infective dyes in the time of COVID |
title_full | Anti-infective dyes in the time of COVID |
title_fullStr | Anti-infective dyes in the time of COVID |
title_full_unstemmed | Anti-infective dyes in the time of COVID |
title_short | Anti-infective dyes in the time of COVID |
title_sort | anti-infective dyes in the time of covid |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447552/ https://www.ncbi.nlm.nih.gov/pubmed/34548711 http://dx.doi.org/10.1016/j.dyepig.2021.109813 |
work_keys_str_mv | AT wainwrightmark antiinfectivedyesinthetimeofcovid |