Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

BACKGROUND: The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects. METHODS: To decipher AMPK roles in the heart, we generated a...

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Detalles Bibliográficos
Autores principales: Grimbert, Lucile, Sanz, Maria-Nieves, Gressette, Mélanie, Rucker-Martin, Catherine, Novotova, Marta, Solgadi, Audrey, Karoui, Ahmed, Gomez, Susana, Bedouet, Kaveen, Jacquet, Eric, Lemaire, Christophe, Veksler, Vladimir, Mericskay, Mathias, Ventura-Clapier, Renée, Piquereau, Jérôme, Garnier, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447586/
https://www.ncbi.nlm.nih.gov/pubmed/34535195
http://dx.doi.org/10.1186/s13293-021-00394-z

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