Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is a malignancy of plasma cells that largely remains incurable. The search for new therapeutic targets is therefore essential. In addition to a wide panel of genetic mutations, epigenetic alterations also appear as important players in the development of this cancer...

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Detalles Bibliográficos
Autores principales: Herviou, Laurie, Ovejero, Sara, Izard, Fanny, Karmous-Gadacha, Ouissem, Gourzones, Claire, Bellanger, Celine, De Smedt, Eva, Ma, Anqi, Vincent, Laure, Cartron, Guillaume, Jin, Jian, De Bruyne, Elke, Grimaud, Charlotte, Julien, Eric, Moreaux, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447659/
https://www.ncbi.nlm.nih.gov/pubmed/34530900
http://dx.doi.org/10.1186/s13148-021-01160-z

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