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The effective function of circular RNA in colorectal cancer
Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447721/ https://www.ncbi.nlm.nih.gov/pubmed/34535136 http://dx.doi.org/10.1186/s12935-021-02196-0 |
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author | Ameli-Mojarad, Mandana Ameli-Mojarad, Melika Hadizadeh, Mahrooyeh Young, Chris Babini, Hosna Nazemalhosseini-Mojarad, Ehsan Bonab, Maziar Ashrafian |
author_facet | Ameli-Mojarad, Mandana Ameli-Mojarad, Melika Hadizadeh, Mahrooyeh Young, Chris Babini, Hosna Nazemalhosseini-Mojarad, Ehsan Bonab, Maziar Ashrafian |
author_sort | Ameli-Mojarad, Mandana |
collection | PubMed |
description | Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC. |
format | Online Article Text |
id | pubmed-8447721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84477212021-09-20 The effective function of circular RNA in colorectal cancer Ameli-Mojarad, Mandana Ameli-Mojarad, Melika Hadizadeh, Mahrooyeh Young, Chris Babini, Hosna Nazemalhosseini-Mojarad, Ehsan Bonab, Maziar Ashrafian Cancer Cell Int Review Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC. BioMed Central 2021-09-17 /pmc/articles/PMC8447721/ /pubmed/34535136 http://dx.doi.org/10.1186/s12935-021-02196-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Ameli-Mojarad, Mandana Ameli-Mojarad, Melika Hadizadeh, Mahrooyeh Young, Chris Babini, Hosna Nazemalhosseini-Mojarad, Ehsan Bonab, Maziar Ashrafian The effective function of circular RNA in colorectal cancer |
title | The effective function of circular RNA in colorectal cancer |
title_full | The effective function of circular RNA in colorectal cancer |
title_fullStr | The effective function of circular RNA in colorectal cancer |
title_full_unstemmed | The effective function of circular RNA in colorectal cancer |
title_short | The effective function of circular RNA in colorectal cancer |
title_sort | effective function of circular rna in colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447721/ https://www.ncbi.nlm.nih.gov/pubmed/34535136 http://dx.doi.org/10.1186/s12935-021-02196-0 |
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