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Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China

BACKGROUND: This study aimed to investigate the clinical characteristics of 21 deaths and evaluate potential factors affecting disease severity and mortality risk in patients with coronavirus disease (COVID-19). METHODS: This retrospective analysis assessed clinical data of 21 patients who died owin...

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Autores principales: Yang, Feihong, Zou, Hao, Gan, Jiaohong, Zhang, Zhongxiang, Zhao, Yan, Jiang, Cheng, Xia, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447734/
http://dx.doi.org/10.1097/EC9.0000000000000001
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author Yang, Feihong
Zou, Hao
Gan, Jiaohong
Zhang, Zhongxiang
Zhao, Yan
Jiang, Cheng
Xia, Jian
author_facet Yang, Feihong
Zou, Hao
Gan, Jiaohong
Zhang, Zhongxiang
Zhao, Yan
Jiang, Cheng
Xia, Jian
author_sort Yang, Feihong
collection PubMed
description BACKGROUND: This study aimed to investigate the clinical characteristics of 21 deaths and evaluate potential factors affecting disease severity and mortality risk in patients with coronavirus disease (COVID-19). METHODS: This retrospective analysis assessed clinical data of 21 patients who died owing to COVID-19. Disease severity and mortality risk were assessed using Acute Physiology and Chronic Health Evaluation II (APACHE II); Sepsis-related Organ Failure Assessment (SOFA); multilobular infiltration, hypo-lymphocytosis, bacterial coinfection, smoking history, hypertension and age (MuLBSTA); and pneumonia severity index (PSI) scores. RESULTS: The mean age of the patients was 66 ± 14 years and 15 (71.4%) patients were men. Sixteen (76.2%) patients had chronic medical illnesses. Twelve (57.1%) patients were overweight. Decreased lymphocyte proportions were observed in 17 (81.0%) patients on admission. Elevated D-dimer levels were observed in 11 (52.4%) patients, and the levels significantly increased when pneumonia deteriorated. The initial APACHE II and SOFA scores demonstrated that 18 (85.7%) and 13 (61.9%) patients, respectively, were in the middle-risk level. MuLBSTA and PSI scores after admission were associated with higher risks of mortality in 13 (61.9%) patients. Most patients developed organ failure and subsequently died. CONCLUSIONS: Older, overweight, male patients with a history of chronic illnesses and continuously decreased lymphocyte proportions and increased D-dimer levels might have higher risks of death owing to COVID-19. The combination of general scoring (SOFA) and pneumonia-specific scoring (MuLBSTA and PSI) systems after admission might be sensitive in assessing the mortality risk of patients with COVID-19 who are in critical condition.
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spelling pubmed-84477342021-09-20 Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China Yang, Feihong Zou, Hao Gan, Jiaohong Zhang, Zhongxiang Zhao, Yan Jiang, Cheng Xia, Jian Emergency and Critical Care Medicine Original Article BACKGROUND: This study aimed to investigate the clinical characteristics of 21 deaths and evaluate potential factors affecting disease severity and mortality risk in patients with coronavirus disease (COVID-19). METHODS: This retrospective analysis assessed clinical data of 21 patients who died owing to COVID-19. Disease severity and mortality risk were assessed using Acute Physiology and Chronic Health Evaluation II (APACHE II); Sepsis-related Organ Failure Assessment (SOFA); multilobular infiltration, hypo-lymphocytosis, bacterial coinfection, smoking history, hypertension and age (MuLBSTA); and pneumonia severity index (PSI) scores. RESULTS: The mean age of the patients was 66 ± 14 years and 15 (71.4%) patients were men. Sixteen (76.2%) patients had chronic medical illnesses. Twelve (57.1%) patients were overweight. Decreased lymphocyte proportions were observed in 17 (81.0%) patients on admission. Elevated D-dimer levels were observed in 11 (52.4%) patients, and the levels significantly increased when pneumonia deteriorated. The initial APACHE II and SOFA scores demonstrated that 18 (85.7%) and 13 (61.9%) patients, respectively, were in the middle-risk level. MuLBSTA and PSI scores after admission were associated with higher risks of mortality in 13 (61.9%) patients. Most patients developed organ failure and subsequently died. CONCLUSIONS: Older, overweight, male patients with a history of chronic illnesses and continuously decreased lymphocyte proportions and increased D-dimer levels might have higher risks of death owing to COVID-19. The combination of general scoring (SOFA) and pneumonia-specific scoring (MuLBSTA and PSI) systems after admission might be sensitive in assessing the mortality risk of patients with COVID-19 who are in critical condition. 2021-09-15 /pmc/articles/PMC8447734/ http://dx.doi.org/10.1097/EC9.0000000000000001 Text en Copyright © 2021 Shandong University, published by Wolters Kluwer, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Original Article
Yang, Feihong
Zou, Hao
Gan, Jiaohong
Zhang, Zhongxiang
Zhao, Yan
Jiang, Cheng
Xia, Jian
Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title_full Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title_fullStr Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title_full_unstemmed Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title_short Important scoring systems for assessing the severity of COVID-19 based on COVID-19-related deaths in Wuhan, China
title_sort important scoring systems for assessing the severity of covid-19 based on covid-19-related deaths in wuhan, china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447734/
http://dx.doi.org/10.1097/EC9.0000000000000001
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