Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

BACKGROUND: Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in the gut microbiome have been implicated in the development of NAFLD/NASH, although the underlying mechanisms remain unclear....

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Detalles Bibliográficos
Autores principales: Aoki, Ryo, Onuki, Masayoshi, Hattori, Koya, Ito, Masato, Yamada, Takahiro, Kamikado, Kohei, Kim, Yun-Gi, Nakamoto, Nobuhiro, Kimura, Ikuo, Clarke, Julie M., Kanai, Takanori, Hase, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447789/
https://www.ncbi.nlm.nih.gov/pubmed/34530928
http://dx.doi.org/10.1186/s40168-021-01125-7

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