Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021

We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10(−6)). In sy...

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Autores principales: Blanquart, François, Abad, Clémence, Ambroise, Joëvin, Bernard, Mathieu, Cosentino, Gina, Giannoli, Jean-Marc, Débarre, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447828/
https://www.ncbi.nlm.nih.gov/pubmed/34533119
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.37.2100824
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author Blanquart, François
Abad, Clémence
Ambroise, Joëvin
Bernard, Mathieu
Cosentino, Gina
Giannoli, Jean-Marc
Débarre, Florence
author_facet Blanquart, François
Abad, Clémence
Ambroise, Joëvin
Bernard, Mathieu
Cosentino, Gina
Giannoli, Jean-Marc
Débarre, Florence
author_sort Blanquart, François
collection PubMed
description We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10(−6)). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10(−6)).
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spelling pubmed-84478282021-10-13 Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021 Blanquart, François Abad, Clémence Ambroise, Joëvin Bernard, Mathieu Cosentino, Gina Giannoli, Jean-Marc Débarre, Florence Euro Surveill Rapid Communication We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10(−6)). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10(−6)). European Centre for Disease Prevention and Control (ECDC) 2021-09-16 /pmc/articles/PMC8447828/ /pubmed/34533119 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.37.2100824 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Blanquart, François
Abad, Clémence
Ambroise, Joëvin
Bernard, Mathieu
Cosentino, Gina
Giannoli, Jean-Marc
Débarre, Florence
Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title_full Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title_fullStr Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title_full_unstemmed Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title_short Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
title_sort characterisation of vaccine breakthrough infections of sars-cov-2 delta and alpha variants and within-host viral load dynamics in the community, france, june to july 2021
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447828/
https://www.ncbi.nlm.nih.gov/pubmed/34533119
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.37.2100824
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