Cargando…

Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases

Increasing evidence shows that endothelial cells play critical roles in maintaining vascular homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid leakage, and preventing thrombosis. The damage or injury of endothelial cells induced by physical, chemical, and bio...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Juan, Pan, Xue, Li, Guoping, Chatterjee, Emeli, Xiao, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447895/
https://www.ncbi.nlm.nih.gov/pubmed/34533746
http://dx.doi.org/10.1007/s12265-021-10171-3
_version_ 1784569114084245504
author Gao, Juan
Pan, Xue
Li, Guoping
Chatterjee, Emeli
Xiao, Junjie
author_facet Gao, Juan
Pan, Xue
Li, Guoping
Chatterjee, Emeli
Xiao, Junjie
author_sort Gao, Juan
collection PubMed
description Increasing evidence shows that endothelial cells play critical roles in maintaining vascular homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid leakage, and preventing thrombosis. The damage or injury of endothelial cells induced by physical, chemical, and biological risk factors is a leading contributor to the development of mortal cardiovascular and cerebrovascular diseases. However, the underlying mechanism of endothelial injury remains to be elucidated. Notably, no drugs effectively targeting and mending injured vascular endothelial cells have been approved for clinical practice. There is an urgent need to understand pathways important for repairing injured vasculature that can be targeted with novel therapies. Exercise training-induced protection to endothelial injury has been well documented in clinical trials, and the underlying mechanism has been explored in animal models. This review mainly summarizes the protective effects of exercise on vascular endothelium and the recently identified potential therapeutic targets for endothelial dysfunction.
format Online
Article
Text
id pubmed-8447895
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-84478952021-09-17 Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases Gao, Juan Pan, Xue Li, Guoping Chatterjee, Emeli Xiao, Junjie J Cardiovasc Transl Res Review Increasing evidence shows that endothelial cells play critical roles in maintaining vascular homeostasis, regulating vascular tone, inhibiting inflammatory response, suppressing lipid leakage, and preventing thrombosis. The damage or injury of endothelial cells induced by physical, chemical, and biological risk factors is a leading contributor to the development of mortal cardiovascular and cerebrovascular diseases. However, the underlying mechanism of endothelial injury remains to be elucidated. Notably, no drugs effectively targeting and mending injured vascular endothelial cells have been approved for clinical practice. There is an urgent need to understand pathways important for repairing injured vasculature that can be targeted with novel therapies. Exercise training-induced protection to endothelial injury has been well documented in clinical trials, and the underlying mechanism has been explored in animal models. This review mainly summarizes the protective effects of exercise on vascular endothelium and the recently identified potential therapeutic targets for endothelial dysfunction. Springer US 2021-09-17 2022 /pmc/articles/PMC8447895/ /pubmed/34533746 http://dx.doi.org/10.1007/s12265-021-10171-3 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Gao, Juan
Pan, Xue
Li, Guoping
Chatterjee, Emeli
Xiao, Junjie
Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title_full Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title_fullStr Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title_full_unstemmed Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title_short Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
title_sort physical exercise protects against endothelial dysfunction in cardiovascular and metabolic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447895/
https://www.ncbi.nlm.nih.gov/pubmed/34533746
http://dx.doi.org/10.1007/s12265-021-10171-3
work_keys_str_mv AT gaojuan physicalexerciseprotectsagainstendothelialdysfunctionincardiovascularandmetabolicdiseases
AT panxue physicalexerciseprotectsagainstendothelialdysfunctionincardiovascularandmetabolicdiseases
AT liguoping physicalexerciseprotectsagainstendothelialdysfunctionincardiovascularandmetabolicdiseases
AT chatterjeeemeli physicalexerciseprotectsagainstendothelialdysfunctionincardiovascularandmetabolicdiseases
AT xiaojunjie physicalexerciseprotectsagainstendothelialdysfunctionincardiovascularandmetabolicdiseases