Influence of stereochemistry on the activity of rapadocin, an isoform-specific inhibitor of the nucleoside transporter ENT1

Rapadocin is a novel rapamycin-inspired polyketide–tetrapeptide hybrid macrocycle that possesses highly potent and isoform-specific inhibitory activity against the human equilibrative nucleoside transporter 1 (hENT1). Rapadocin contains an epimerizable chiral center in phenylglycine and an olefin gr...

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Detalles Bibliográficos
Autores principales: Wang, Yuefan, Peng, Hanjing, Guo, Zufeng, Ullman, Brett R., Yamamoto, Kana, Hong, Sam Y., Liu, Jun O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447900/
https://www.ncbi.nlm.nih.gov/pubmed/34667552
http://dx.doi.org/10.1039/d1sc02295d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447900/
https://www.ncbi.nlm.nih.gov/pubmed/34667552
http://dx.doi.org/10.1039/d1sc02295d

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