Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes

Xenon is confirmed to diffuse readily through membranes and has properties of transdermal enhancer. In this study, the ability of xenon to regulate the transdermal diffusion of niacinamide was investigated using a model of an artificial skin analogue of Strat-M™ membranes in Franz cells. Based on th...

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Autores principales: Petrov, Evgeny, Verkhovskiy, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447954/
https://www.ncbi.nlm.nih.gov/pubmed/34472499
http://dx.doi.org/10.4103/2045-9912.320704
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author Petrov, Evgeny
Verkhovskiy, Alexander
author_facet Petrov, Evgeny
Verkhovskiy, Alexander
author_sort Petrov, Evgeny
collection PubMed
description Xenon is confirmed to diffuse readily through membranes and has properties of transdermal enhancer. In this study, the ability of xenon to regulate the transdermal diffusion of niacinamide was investigated using a model of an artificial skin analogue of Strat-M™ membranes in Franz cells. Based on the data obtained, we found that in the simplified biophysical model of Strat-M™ membranes xenon exerts its enhancer effect based on the heterogeneous nucleation of xenon at the interfaces in the microporous structures of Strat-M™ membranes.
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spelling pubmed-84479542021-10-06 Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes Petrov, Evgeny Verkhovskiy, Alexander Med Gas Res Research Article Xenon is confirmed to diffuse readily through membranes and has properties of transdermal enhancer. In this study, the ability of xenon to regulate the transdermal diffusion of niacinamide was investigated using a model of an artificial skin analogue of Strat-M™ membranes in Franz cells. Based on the data obtained, we found that in the simplified biophysical model of Strat-M™ membranes xenon exerts its enhancer effect based on the heterogeneous nucleation of xenon at the interfaces in the microporous structures of Strat-M™ membranes. Wolters Kluwer - Medknow 2021-08-30 /pmc/articles/PMC8447954/ /pubmed/34472499 http://dx.doi.org/10.4103/2045-9912.320704 Text en Copyright: © 2022 Medical Gas Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Petrov, Evgeny
Verkhovskiy, Alexander
Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title_full Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title_fullStr Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title_full_unstemmed Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title_short Xenon as a transdermal enhancer for niacinamide in Strat-M™ membranes
title_sort xenon as a transdermal enhancer for niacinamide in strat-m™ membranes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447954/
https://www.ncbi.nlm.nih.gov/pubmed/34472499
http://dx.doi.org/10.4103/2045-9912.320704
work_keys_str_mv AT petrovevgeny xenonasatransdermalenhancerforniacinamideinstratmmembranes
AT verkhovskiyalexander xenonasatransdermalenhancerforniacinamideinstratmmembranes

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