Cargando…

Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis

BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evide...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Shu, Gou, Lianping, Liu, Shiping, Cao, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448001/
https://www.ncbi.nlm.nih.gov/pubmed/34664847
http://dx.doi.org/10.1097/MD.0000000000027196
_version_ 1784569144176279552
author Luo, Shu
Gou, Lianping
Liu, Shiping
Cao, Xiaoping
author_facet Luo, Shu
Gou, Lianping
Liu, Shiping
Cao, Xiaoping
author_sort Luo, Shu
collection PubMed
description BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evidence is scant. Herein, we designed the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, aiming to systematically evaluate the efficacy and safety of SFI in patients with sepsis. METHODS: Eligible studies reporting the efficacy and safety of SFI in the treatment of sepsis published before August 2021 will be searched from online databases, including the PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. The literature selection process will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. After data extraction and methodological quality evaluation, Stata 12.0 software will be used to synthesize the data through fixed/random effects of meta-analysis models. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This study will provide reliable evidence-based basis for the clinical application of SFI in the treatment of sepsis. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/KCMDQ.
format Online
Article
Text
id pubmed-8448001
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-84480012021-09-20 Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis Luo, Shu Gou, Lianping Liu, Shiping Cao, Xiaoping Medicine (Baltimore) 3800 BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evidence is scant. Herein, we designed the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, aiming to systematically evaluate the efficacy and safety of SFI in patients with sepsis. METHODS: Eligible studies reporting the efficacy and safety of SFI in the treatment of sepsis published before August 2021 will be searched from online databases, including the PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. The literature selection process will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. After data extraction and methodological quality evaluation, Stata 12.0 software will be used to synthesize the data through fixed/random effects of meta-analysis models. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This study will provide reliable evidence-based basis for the clinical application of SFI in the treatment of sepsis. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/KCMDQ. Lippincott Williams & Wilkins 2021-09-17 /pmc/articles/PMC8448001/ /pubmed/34664847 http://dx.doi.org/10.1097/MD.0000000000027196 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 3800
Luo, Shu
Gou, Lianping
Liu, Shiping
Cao, Xiaoping
Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title_full Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title_fullStr Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title_full_unstemmed Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title_short Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
title_sort efficacy and safety of shenfu injection in the treatment of sepsis: a protocol for systematic review and meta-analysis
topic 3800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448001/
https://www.ncbi.nlm.nih.gov/pubmed/34664847
http://dx.doi.org/10.1097/MD.0000000000027196
work_keys_str_mv AT luoshu efficacyandsafetyofshenfuinjectioninthetreatmentofsepsisaprotocolforsystematicreviewandmetaanalysis
AT goulianping efficacyandsafetyofshenfuinjectioninthetreatmentofsepsisaprotocolforsystematicreviewandmetaanalysis
AT liushiping efficacyandsafetyofshenfuinjectioninthetreatmentofsepsisaprotocolforsystematicreviewandmetaanalysis
AT caoxiaoping efficacyandsafetyofshenfuinjectioninthetreatmentofsepsisaprotocolforsystematicreviewandmetaanalysis