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Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis
BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evide...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448001/ https://www.ncbi.nlm.nih.gov/pubmed/34664847 http://dx.doi.org/10.1097/MD.0000000000027196 |
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author | Luo, Shu Gou, Lianping Liu, Shiping Cao, Xiaoping |
author_facet | Luo, Shu Gou, Lianping Liu, Shiping Cao, Xiaoping |
author_sort | Luo, Shu |
collection | PubMed |
description | BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evidence is scant. Herein, we designed the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, aiming to systematically evaluate the efficacy and safety of SFI in patients with sepsis. METHODS: Eligible studies reporting the efficacy and safety of SFI in the treatment of sepsis published before August 2021 will be searched from online databases, including the PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. The literature selection process will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. After data extraction and methodological quality evaluation, Stata 12.0 software will be used to synthesize the data through fixed/random effects of meta-analysis models. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This study will provide reliable evidence-based basis for the clinical application of SFI in the treatment of sepsis. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/KCMDQ. |
format | Online Article Text |
id | pubmed-8448001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-84480012021-09-20 Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis Luo, Shu Gou, Lianping Liu, Shiping Cao, Xiaoping Medicine (Baltimore) 3800 BACKGROUND: Sepsis is a syndrome of infection-induced systemic inflammatory response. Conventional treatment combined with Shenfu injection (SFI) has been previously validated clinical effective in alleviating inflammatory response in patients with septic shock. However, evidence-based medical evidence is scant. Herein, we designed the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, aiming to systematically evaluate the efficacy and safety of SFI in patients with sepsis. METHODS: Eligible studies reporting the efficacy and safety of SFI in the treatment of sepsis published before August 2021 will be searched from online databases, including the PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, Wanfang Database, China National Knowledge Infrastructure, and China Biology Medicine Disc. The literature selection process will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. After data extraction and methodological quality evaluation, Stata 12.0 software will be used to synthesize the data through fixed/random effects of meta-analysis models. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This study will provide reliable evidence-based basis for the clinical application of SFI in the treatment of sepsis. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/KCMDQ. Lippincott Williams & Wilkins 2021-09-17 /pmc/articles/PMC8448001/ /pubmed/34664847 http://dx.doi.org/10.1097/MD.0000000000027196 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 3800 Luo, Shu Gou, Lianping Liu, Shiping Cao, Xiaoping Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title | Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title_full | Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title_fullStr | Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title_full_unstemmed | Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title_short | Efficacy and safety of Shenfu injection in the treatment of sepsis: A protocol for systematic review and meta-analysis |
title_sort | efficacy and safety of shenfu injection in the treatment of sepsis: a protocol for systematic review and meta-analysis |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448001/ https://www.ncbi.nlm.nih.gov/pubmed/34664847 http://dx.doi.org/10.1097/MD.0000000000027196 |
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