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Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease
The association between stopping statins and 1-year mortality in the general population of the oldest-old – with or without ischemic heart disease (IHD) – has been studied herein for the first time. This was a retrospective study. Included were all consecutive patients (n = 369) aged 80 years or mor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448040/ https://www.ncbi.nlm.nih.gov/pubmed/34664827 http://dx.doi.org/10.1097/MD.0000000000026966 |
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author | Ioffe, Marina Kremer, Anjelika Nachimov, Irena Swartzon, Michael Justo, Dan |
author_facet | Ioffe, Marina Kremer, Anjelika Nachimov, Irena Swartzon, Michael Justo, Dan |
author_sort | Ioffe, Marina |
collection | PubMed |
description | The association between stopping statins and 1-year mortality in the general population of the oldest-old – with or without ischemic heart disease (IHD) – has been studied herein for the first time. This was a retrospective study. Included were all consecutive patients (n = 369) aged 80 years or more (mean age 87.8 years) hospitalized in a single Geriatrics department during 1 year. The study group included 140 patients in whom statins were stopped upon admission (statin stoppers). The control group included 229 patients who did not use statins in the first place (statin non-users). All-cause 1-year mortality rates were studied in both groups following propensity score matching and in IHD patients separately. Overall, 110 (29.8%) patients died during the year following admission: 38 (27.1%) statin stoppers and 72 (31.4%) statin non-users (P = .498). Cox regression analysis showed no association between stopping statins and 1-year mortality in the crude analysis (hazard ratio [HR] 0.976, 95% confidence interval [CI] 0.651–1.463, P = .907) and following propensity score matching (HR 1.067, 95%CI 0.674–1.689, P = .782). Among 108 IHD patients, 38 (35.2%) patients died during the year following admission: 18 (27.7%) statin stoppers and 20 (46.5%) statin non-users (P = .059). Cox regression analysis showed a nearly significant association between stopping statins (rather than not using statins) in IHD patients and lower 1-year mortality (HR 0.524, 95%CI 0.259–1.060, P = .072). Hence, stopping statins in the general population of the oldest-old – with or without IHD – is possibly safe. Future studies including the oldest-old statin continuers are warranted to confirm this observation. |
format | Online Article Text |
id | pubmed-8448040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-84480402021-09-20 Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease Ioffe, Marina Kremer, Anjelika Nachimov, Irena Swartzon, Michael Justo, Dan Medicine (Baltimore) 4600 The association between stopping statins and 1-year mortality in the general population of the oldest-old – with or without ischemic heart disease (IHD) – has been studied herein for the first time. This was a retrospective study. Included were all consecutive patients (n = 369) aged 80 years or more (mean age 87.8 years) hospitalized in a single Geriatrics department during 1 year. The study group included 140 patients in whom statins were stopped upon admission (statin stoppers). The control group included 229 patients who did not use statins in the first place (statin non-users). All-cause 1-year mortality rates were studied in both groups following propensity score matching and in IHD patients separately. Overall, 110 (29.8%) patients died during the year following admission: 38 (27.1%) statin stoppers and 72 (31.4%) statin non-users (P = .498). Cox regression analysis showed no association between stopping statins and 1-year mortality in the crude analysis (hazard ratio [HR] 0.976, 95% confidence interval [CI] 0.651–1.463, P = .907) and following propensity score matching (HR 1.067, 95%CI 0.674–1.689, P = .782). Among 108 IHD patients, 38 (35.2%) patients died during the year following admission: 18 (27.7%) statin stoppers and 20 (46.5%) statin non-users (P = .059). Cox regression analysis showed a nearly significant association between stopping statins (rather than not using statins) in IHD patients and lower 1-year mortality (HR 0.524, 95%CI 0.259–1.060, P = .072). Hence, stopping statins in the general population of the oldest-old – with or without IHD – is possibly safe. Future studies including the oldest-old statin continuers are warranted to confirm this observation. Lippincott Williams & Wilkins 2021-09-17 /pmc/articles/PMC8448040/ /pubmed/34664827 http://dx.doi.org/10.1097/MD.0000000000026966 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | 4600 Ioffe, Marina Kremer, Anjelika Nachimov, Irena Swartzon, Michael Justo, Dan Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title | Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title_full | Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title_fullStr | Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title_full_unstemmed | Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title_short | Mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
title_sort | mortality associated with stopping statins in the oldest-old – with and without ischemic heart disease |
topic | 4600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448040/ https://www.ncbi.nlm.nih.gov/pubmed/34664827 http://dx.doi.org/10.1097/MD.0000000000026966 |
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