Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-Up

Activated PI3K-kinase Delta Syndrome (APDS) is an autosomal-dominant primary immunodeficiency (PID) caused by the constitutive activation of the PI3Kδ kinase. The consequent hyperactivation of the PI3K-Akt-mTOR pathway leads to an impaired T- and B-cells differentiation and function, causing progres...

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Detalles Bibliográficos
Autores principales: Rivalta, Beatrice, Amodio, Donato, Milito, Cinzia, Chiriaco, Maria, Di Cesare, Silvia, Giancotta, Carmela, Conti, Francesca, Santilli, Veronica, Pacillo, Lucia, Cifaldi, Cristina, Desimio, Maria Giovanna, Doria, Margherita, Quinti, Isabella, De Vito, Rita, Di Matteo, Gigliola, Finocchi, Andrea, Palma, Paolo, Trizzino, Antonino, Tommasini, Alberto, Cancrini, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448282/
https://www.ncbi.nlm.nih.gov/pubmed/34540765
http://dx.doi.org/10.3389/fped.2021.703853

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