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Polygenetic risk scores do not add predictive power to clinical models for response to anti-TNFα therapy in inflammatory bowel disease

BACKGROUND: Anti-tumour necrosis factor alpha (TNFα) therapy is widely used in the management of Crohn’s disease (CD) and ulcerative colitis (UC). However, up to a third of patients do not respond to induction therapy and another third of patients lose response over time. To aid patient stratificati...

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Detalles Bibliográficos
Autores principales:	Karmi, Naomi, Bangma, Amber, Spekhorst, Lieke M., van Dullemen, Hendrik M., Visschedijk, Marijn C., Dijkstra, Gerard, Weersma, Rinse K., Voskuil, Michiel D., Festen, Eleonora A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448323/ https://www.ncbi.nlm.nih.gov/pubmed/34534227 http://dx.doi.org/10.1371/journal.pone.0256860

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