Cargando…
High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology
Incorporation of noncanonical amino acids (ncAAs) can endow proteins with novel functionalities, such as crosslinking or fluorescence. In ion channels, the function of these variants can be studied with great precision using standard electrophysiology, but this approach is typically labor intensive...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448361/ https://www.ncbi.nlm.nih.gov/pubmed/34491979 http://dx.doi.org/10.1371/journal.pbio.3001321 |