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Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

BACKGROUND: Cardiovascular risk in diabetes remains elevated despite glucose-lowering therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages, promoting persistent proatherogenic characteristics. METHODS: Bone marrow–derived macrophages from control mice and mice with d...

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Detalles Bibliográficos
Autores principales:	Edgar, Laurienne, Akbar, Naveed, Braithwaite, Adam T., Krausgruber, Thomas, Gallart-Ayala, Héctor, Bailey, Jade, Corbin, Alastair L., Khoyratty, Tariq E., Chai, Joshua T., Alkhalil, Mohammad, Rendeiro, André F., Ziberna, Klemen, Arya, Ritu, Cahill, Thomas J., Bock, Christoph, Laurencikiene, Jurga, Crabtree, Mark J., Lemieux, Madeleine E., Riksen, Niels P., Netea, Mihai G., Wheelock, Craig E., Channon, Keith M., Rydén, Mikael, Udalova, Irina A., Carnicer, Ricardo, Choudhury, Robin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448412/ https://www.ncbi.nlm.nih.gov/pubmed/34255973 http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046464

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