Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer

Glucuronidation controls androgen levels in the prostate and the dysregulation of enzymes in this pathway is associated with castration resistant prostate cancer. UDP-glucose dehydrogenase (UGDH) produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression is elevated in...

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Detalles Bibliográficos
Autores principales: Zimmer, Brenna M., Howell, Michelle E., Ma, Linlin, Enders, Jeffrey R., Lehman, Danielle, Corey, Eva, Barycki, Joseph J., Simpson, Melanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448517/
https://www.ncbi.nlm.nih.gov/pubmed/34548906
http://dx.doi.org/10.18632/oncotarget.28059

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