Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

Tagging of endogenous stress response genes can provide valuable in vitro models for chemical safety assessment. Here, we present the generation and application of a fluorescent human induced pluripotent stem cell (hiPSC) reporter line for Heme oxygenase-1 (HMOX1), which is considered a sensitive an...

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Detalles Bibliográficos
Autores principales: Snijders, Kirsten E., Fehér, Anita, Táncos, Zsuzsanna, Bock, István, Téglási, Annamária, van den Berk, Linda, Niemeijer, Marije, Bouwman, Peter, Le Dévédec, Sylvia E., Moné, Martijn J., Van Rossom, Rob, Kumar, Manoj, Wilmes, Anja, Jennings, Paul, Verfaillie, Catherine M., Kobolák, Julianna, ter Braak, Bas, Dinnyés, András, van de Water, Bob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448683/
https://www.ncbi.nlm.nih.gov/pubmed/34480604
http://dx.doi.org/10.1007/s00204-021-03127-8

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