A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Genetic screens are often performed in transformed cell lines that poorly represent viral target cells in vivo, leading to discoveries that may not be translated to the clinic...

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Detalles Bibliográficos
Autores principales: Beumer, Joep, Geurts, Maarten H., Lamers, Mart M., Puschhof, Jens, Zhang, Jingshu, van der Vaart, Jelte, Mykytyn, Anna Z., Breugem, Tim I., Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B., de Lau, Wim, Pleguezuelos-Manzano, Cayetano, Busslinger, Georg, Haagmans, Bart L., Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448725/
https://www.ncbi.nlm.nih.gov/pubmed/34535662
http://dx.doi.org/10.1038/s41467-021-25729-7

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