Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was d...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahuno, Samuel Terkper, Doebley, Anna-Lisa, Ahearn, Thomas U., Yarney, Joel, Titiloye, Nicholas, Hamel, Nancy, Adjei, Ernest, Clegg-Lamptey, Joe-Nat, Edusei, Lawrence, Awuah, Baffour, Song, Xiaoyu, Vanderpuye, Verna, Abubakar, Mustapha, Duggan, Maire, Stover, Daniel G., Nyarko, Kofi, Bartlett, John M. S., Aitpillah, Francis, Ansong, Daniel, Gardner, Kevin L., Boateng, Felix Andy, Bowcock, Anne M., Caldas, Carlos, Foulkes, William D., Wiafe, Seth, Wiafe-Addai, Beatrice, Garcia-Closas, Montserrat, Kwarteng, Alexander, Ha, Gavin, Figueroa, Jonine D., Polak, Paz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448727/
https://www.ncbi.nlm.nih.gov/pubmed/34535742
http://dx.doi.org/10.1038/s41698-021-00219-7
Descripción
Sumario:Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

Ejemplares similares