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Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was d...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448727/ https://www.ncbi.nlm.nih.gov/pubmed/34535742 http://dx.doi.org/10.1038/s41698-021-00219-7 |
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| author | Ahuno, Samuel Terkper Doebley, Anna-Lisa Ahearn, Thomas U. Yarney, Joel Titiloye, Nicholas Hamel, Nancy Adjei, Ernest Clegg-Lamptey, Joe-Nat Edusei, Lawrence Awuah, Baffour Song, Xiaoyu Vanderpuye, Verna Abubakar, Mustapha Duggan, Maire Stover, Daniel G. Nyarko, Kofi Bartlett, John M. S. Aitpillah, Francis Ansong, Daniel Gardner, Kevin L. Boateng, Felix Andy Bowcock, Anne M. Caldas, Carlos Foulkes, William D. Wiafe, Seth Wiafe-Addai, Beatrice Garcia-Closas, Montserrat Kwarteng, Alexander Ha, Gavin Figueroa, Jonine D. Polak, Paz |
| author_facet | Ahuno, Samuel Terkper Doebley, Anna-Lisa Ahearn, Thomas U. Yarney, Joel Titiloye, Nicholas Hamel, Nancy Adjei, Ernest Clegg-Lamptey, Joe-Nat Edusei, Lawrence Awuah, Baffour Song, Xiaoyu Vanderpuye, Verna Abubakar, Mustapha Duggan, Maire Stover, Daniel G. Nyarko, Kofi Bartlett, John M. S. Aitpillah, Francis Ansong, Daniel Gardner, Kevin L. Boateng, Felix Andy Bowcock, Anne M. Caldas, Carlos Foulkes, William D. Wiafe, Seth Wiafe-Addai, Beatrice Garcia-Closas, Montserrat Kwarteng, Alexander Ha, Gavin Figueroa, Jonine D. Polak, Paz |
| author_sort | Ahuno, Samuel Terkper |
| collection | PubMed |
| description | Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients. |
| format | Online Article Text |
| id | pubmed-8448727 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84487272021-10-04 Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa Ahuno, Samuel Terkper Doebley, Anna-Lisa Ahearn, Thomas U. Yarney, Joel Titiloye, Nicholas Hamel, Nancy Adjei, Ernest Clegg-Lamptey, Joe-Nat Edusei, Lawrence Awuah, Baffour Song, Xiaoyu Vanderpuye, Verna Abubakar, Mustapha Duggan, Maire Stover, Daniel G. Nyarko, Kofi Bartlett, John M. S. Aitpillah, Francis Ansong, Daniel Gardner, Kevin L. Boateng, Felix Andy Bowcock, Anne M. Caldas, Carlos Foulkes, William D. Wiafe, Seth Wiafe-Addai, Beatrice Garcia-Closas, Montserrat Kwarteng, Alexander Ha, Gavin Figueroa, Jonine D. Polak, Paz NPJ Precis Oncol Brief Communication Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients. Nature Publishing Group UK 2021-09-17 /pmc/articles/PMC8448727/ /pubmed/34535742 http://dx.doi.org/10.1038/s41698-021-00219-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Brief Communication Ahuno, Samuel Terkper Doebley, Anna-Lisa Ahearn, Thomas U. Yarney, Joel Titiloye, Nicholas Hamel, Nancy Adjei, Ernest Clegg-Lamptey, Joe-Nat Edusei, Lawrence Awuah, Baffour Song, Xiaoyu Vanderpuye, Verna Abubakar, Mustapha Duggan, Maire Stover, Daniel G. Nyarko, Kofi Bartlett, John M. S. Aitpillah, Francis Ansong, Daniel Gardner, Kevin L. Boateng, Felix Andy Bowcock, Anne M. Caldas, Carlos Foulkes, William D. Wiafe, Seth Wiafe-Addai, Beatrice Garcia-Closas, Montserrat Kwarteng, Alexander Ha, Gavin Figueroa, Jonine D. Polak, Paz Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title | Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title_full | Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title_fullStr | Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title_full_unstemmed | Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title_short | Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa |
| title_sort | circulating tumor dna is readily detectable among ghanaian breast cancer patients supporting non-invasive cancer genomic studies in africa |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448727/ https://www.ncbi.nlm.nih.gov/pubmed/34535742 http://dx.doi.org/10.1038/s41698-021-00219-7 |
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