Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates telomerase-dependent telomere extension. Mice possess two functionally distinct POT1 proteins. POT1a represses ATR/CHK1 DNA damage responses and the al...

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Detalles Bibliográficos
Autores principales: Gu, Peili, Jia, Shuting, Takasugi, Taylor, Tesmer, Valerie M., Nandakumar, Jayakrishnan, Chen, Yong, Chang, Sandy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448735/
https://www.ncbi.nlm.nih.gov/pubmed/34535663
http://dx.doi.org/10.1038/s41467-021-25799-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448735/
https://www.ncbi.nlm.nih.gov/pubmed/34535663
http://dx.doi.org/10.1038/s41467-021-25799-7

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