Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

PTEN promoter hypermethylation is nearly universal and PTEN copy number loss occurs in ~25% of fusion-negative rhabdomyosarcoma (FN-RMS). Here we show Pten deletion in a mouse model of FN-RMS results in less differentiated tumors more closely resembling human embryonal RMS. PTEN loss activated the P...

Descripción completa

Detalles Bibliográficos
Autores principales: Langdon, Casey G., Gadek, Katherine E., Garcia, Matthew R., Evans, Myron K., Reed, Kristin B., Bush, Madeline, Hanna, Jason A., Drummond, Catherine J., Maguire, Matthew C., Leavey, Patrick J., Finkelstein, David, Jin, Hongjian, Schreiner, Patrick A., Rehg, Jerold E., Hatley, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448747/
https://www.ncbi.nlm.nih.gov/pubmed/34535684
http://dx.doi.org/10.1038/s41467-021-25829-4

Ejemplares similares

Ejemplares similares