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Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression

Knocking down delta-5-desaturase (D5D) by siRNA or shRNA is a promising strategy to achieve 8-hydroxyoctanoic acid (8-HOA) production for cancer inhibition. However, the RNAi-based strategy to stimulate 8-HOA is restricted due to endonucleases mediated physiological degradation and off-target effect...

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Detalles Bibliográficos
Autores principales: Shah, Harshit, Pang, Lizhi, Qian, Steven, Sathish, Venkatachalem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448825/
https://www.ncbi.nlm.nih.gov/pubmed/34535685
http://dx.doi.org/10.1038/s41523-021-00330-9