SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression

Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway. However, the role of sprouty RTK signaling antagonist 4 (SPRY4), an inhibitor of MAPK, in the human cartilage tissues and chondrocytes re...

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Detalles Bibliográficos
Autores principales: Park, Sunghyun, Arai, Yoshie, Bello, Alvin, Park, Hansoo, Kim, Dohyun, Park, Kyung-Soon, Lee, Soo-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448831/
https://www.ncbi.nlm.nih.gov/pubmed/34535669
http://dx.doi.org/10.1038/s41536-021-00165-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448831/
https://www.ncbi.nlm.nih.gov/pubmed/34535669
http://dx.doi.org/10.1038/s41536-021-00165-9

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