Interleukin-34 promotes tumorigenic signals for colon cancer cells

Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mai...

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Autores principales: Franzè, Eleonora, Marafini, Irene, Troncone, Edoardo, Salvatori, Silvia, Monteleone, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448832/
https://www.ncbi.nlm.nih.gov/pubmed/34535634
http://dx.doi.org/10.1038/s41420-021-00636-4
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author Franzè, Eleonora
Marafini, Irene
Troncone, Edoardo
Salvatori, Silvia
Monteleone, Giovanni
author_facet Franzè, Eleonora
Marafini, Irene
Troncone, Edoardo
Salvatori, Silvia
Monteleone, Giovanni
author_sort Franzè, Eleonora
collection PubMed
description Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mainly via the production of cytokines. Interleukin-34 (IL-34), a cytokine known to regulate mainly monocyte/macrophage survival and function, is highly produced within the CRC microenvironment by several cell types, including cancer cells, tumour-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), and regulates the pro-tumoural functions of such cells. In this article, we summarize the available data supporting the multiple effects of IL-34 in human CRC.
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spelling pubmed-84488322021-10-05 Interleukin-34 promotes tumorigenic signals for colon cancer cells Franzè, Eleonora Marafini, Irene Troncone, Edoardo Salvatori, Silvia Monteleone, Giovanni Cell Death Discov Review Article Colorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Accumulating evidence indicates that colon carcinogenesis is tightly controlled by tumour-associated immune cells and stromal cells, which can either stimulate or suppress CRC cell growth and survival, mainly via the production of cytokines. Interleukin-34 (IL-34), a cytokine known to regulate mainly monocyte/macrophage survival and function, is highly produced within the CRC microenvironment by several cell types, including cancer cells, tumour-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), and regulates the pro-tumoural functions of such cells. In this article, we summarize the available data supporting the multiple effects of IL-34 in human CRC. Nature Publishing Group UK 2021-09-17 /pmc/articles/PMC8448832/ /pubmed/34535634 http://dx.doi.org/10.1038/s41420-021-00636-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Franzè, Eleonora
Marafini, Irene
Troncone, Edoardo
Salvatori, Silvia
Monteleone, Giovanni
Interleukin-34 promotes tumorigenic signals for colon cancer cells
title Interleukin-34 promotes tumorigenic signals for colon cancer cells
title_full Interleukin-34 promotes tumorigenic signals for colon cancer cells
title_fullStr Interleukin-34 promotes tumorigenic signals for colon cancer cells
title_full_unstemmed Interleukin-34 promotes tumorigenic signals for colon cancer cells
title_short Interleukin-34 promotes tumorigenic signals for colon cancer cells
title_sort interleukin-34 promotes tumorigenic signals for colon cancer cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448832/
https://www.ncbi.nlm.nih.gov/pubmed/34535634
http://dx.doi.org/10.1038/s41420-021-00636-4
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