Cargando…

Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals

Beta-hemoglobinopathies become prominent after birth due to a switch from γ-globin to the mutated β-globin. Haploinsufficiency for the erythroid specific indispensable transcription factor Krueppel-like factor 1 (KLF1) is associated with high persistence of fetal hemoglobin (HPFH). The In(Lu) phenot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eernstman, Jesse, Veldhuisen, Barbera, Ligthart, Peter, von Lindern, Marieke, van der Schoot, C. Ellen, van den Akker, Emile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448862/ https://www.ncbi.nlm.nih.gov/pubmed/34535703 http://dx.doi.org/10.1038/s41598-021-97149-y

Ejemplares similares

Hemoglobin switching in mice carrying the Klf1Nan variant
por: Korporaal, Anne, et al.
Publicado: (2020)

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells
por: Gallego-Murillo, Joan Sebastián, et al.
Publicado: (2023)

The Shape Shifting Story of Reticulocyte Maturation
por: Ovchynnikova, Elina, et al.
Publicado: (2018)

CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis
por: Heshusius, Steven, et al.
Publicado: (2021)

Identification of a novel single‐nucleotide mutation in SMIM1 gene that results in low Vel antigen expression
por: van der Rijst, Marea V.E., et al.
Publicado: (2019)

S277: IPSC DISEASE MODELS TO STUDY AND TREAT DIAMOND-BLACKFAN ANEMIA SYNDROME (DBAS)
por: Clark, Chantal, et al.
Publicado: (2023)

Haploinsufficiency for the erythroid transcription factor KLF1 causes Hereditary Persistence of Fetal Hemoglobin
por: Borg, Joseph, et al.
Publicado: (2010)

Hereditary persistence of fetal hemoglobin
por: Sharma, Dharmesh Chandra, et al.
Publicado: (2020)

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific
por: Nicolet, Benoit P, et al.
Publicado: (2018)

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages
por: Herta, Toni, et al.
Publicado: (2018)

Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia
por: Herta, Toni, et al.
Publicado: (2021)

Mechanical Stress Induces Ca(2+)-Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis
por: Aglialoro, Francesca, et al.
Publicado: (2021)

Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors
por: Gallego‐Murillo, Joan Sebastián, et al.
Publicado: (2022)

One third of alloantibodies in patients with sickle cell disease transfused with African blood are missed by the standard red blood cell test panel
por: Boateng, Lilian A., et al.
Publicado: (2021)

Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA counterpart in terminal hematopoiesis
por: Nicolet, Benoit P., et al.
Publicado: (2022)

Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart
por: Noack, Claudia, et al.
Publicado: (2012)

Grsf1-Induced Translation of the SNARE Protein Use1 Is Required for Expansion of the Erythroid Compartment
por: Nieradka, Andrzej, et al.
Publicado: (2014)

Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin
por: Shaukat, Irfan, et al.
Publicado: (2018)

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells
por: Abay, Asena, et al.
Publicado: (2019)

Btk Is Required for an Efficient Response to Erythropoietin and for SCF-controlled Protection against TRAIL in Erythroid Progenitors
por: Schmidt, Uwe, et al.
Publicado: (2004)

Correction
por: Schmidt, Uwe, et al.
Publicado: (2004)

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania
por: Nkya, Siana, et al.
Publicado: (2020)

TGFBI Expressed by Bone Marrow Niche Cells and Hematopoietic Stem and Progenitor Cells Regulates Hematopoiesis
por: Klamer, Sofieke E., et al.
Publicado: (2018)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
por: Lu, Dian, et al.
Publicado: (2022)

Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line
por: Moore, Kat S., et al.
Publicado: (2018)

Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands
por: de Haas, Masja, et al.
Publicado: (2016)

Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
por: Heshusius, Steven, et al.
Publicado: (2022)

Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
por: Lopez-Yrigoyen, Martha, et al.
Publicado: (2019)

Kidney absorbed radiation doses for [(177)Lu]Lu-PSMA-617 and [(177)Lu]Lu-PSMA-I&T determined by 3D clinical dosimetry
por: Uijen, Maike J.M., et al.
Publicado: (2023)

The prevalence and molecular characterization of (δβ)(0)‐thalassemia and hereditary persistence of fetal hemoglobin in the Chinese Zhuang population
por: He, Sheng, et al.
Publicado: (2017)

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
por: Doerfler, Phillip A., et al.
Publicado: (2021)

Sickle Cell Disease and Fetal Hemoglobin
por: Rivera, Alicia
Publicado: (2018)

The Role of Translation Initiation Regulation in Haematopoiesis
por: Grech, Godfrey, et al.
Publicado: (2012)

RNA Binding Proteins and Regulation of mRNA Translation in Erythropoiesis
por: Moore, Kat S., et al.
Publicado: (2018)

Improved quality control of [(177)Lu]Lu-PSMA I&T
por: Kraihammer, Martin, et al.
Publicado: (2023)

Intraindividual comparison of [(177)Lu]Lu-DOTA-EB-TATE and [(177)Lu]Lu-DOTA-TOC
por: Hänscheid, Heribert, et al.
Publicado: (2021)

Analysis of deletional hereditary persistence of fetal hemoglobin/δβ‐thalassemia and δ‐globin gene mutations in Southerwestern China
por: Zhang, Jie, et al.
Publicado: (2019)

The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression
por: Hansen, Marten, et al.
Publicado: (2020)

Prevalence of RhD status and clinical application of non-invasive prenatal determination of fetal RHD in maternal plasma: a 5 year experience in Cyprus
por: Papasavva, Thessalia, et al.
Publicado: (2016)

Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin
por: J. Verheul, Thijs C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_sf8or0i3gaphfe7suursjap41n