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Activation mechanism of human soluble guanylate cyclase by stimulators and activators

Soluble guanylate cyclase (sGC) is the receptor for nitric oxide (NO) in human. It is an important validated drug target for cardiovascular diseases. sGC can be pharmacologically activated by stimulators and activators. However, the detailed structural mechanisms, through which sGC is recognized and...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Kang, Yunlu, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448884/
https://www.ncbi.nlm.nih.gov/pubmed/34535643
http://dx.doi.org/10.1038/s41467-021-25617-0

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