Delayed Administration of N-Acetylcysteine Blunts Recovery After an Acetaminophen Overdose Unlike 4-Methylpyrazole

N-acetylcysteine (NAC) is the only clinically approved antidote against acetaminophen (APAP) hepatotoxicity. Despite its efficacy in patients treated early after APAP overdose, NAC has been implicated in impairing liver recovery in mice. More recently, 4-methylpyrazole (4MP, Fomepizole) emerged as a...

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Detalles Bibliográficos
Autores principales: Akakpo, Jephte Y., Jaeschke, Matthew W., Ramachandran, Anup, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448936/
https://www.ncbi.nlm.nih.gov/pubmed/34420083
http://dx.doi.org/10.1007/s00204-021-03142-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448936/
https://www.ncbi.nlm.nih.gov/pubmed/34420083
http://dx.doi.org/10.1007/s00204-021-03142-9

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