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Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy

PURPOSE: Immunotherapies mediate the regression of human tumors through recognition of tumor antigens by immune cells that trigger an immune response. Mutations in the RAS oncogenes occur in about 30% of all patients with cancer. These mutations play an important role in both tumor establishment and...

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Detalles Bibliográficos
Autores principales:	Levin, Noam, Paria, Biman C., Vale, Nolan R., Yossef, Rami, Lowery, Frank J., Parkhurst, Maria R., Yu, Zhiya, Florentin, Maria, Cafri, Gal, Gartner, Jared J., Shindorf, Mackenzie L., Ngo, Lien T., Ray, Satyajit, Kim, Sanghyun P., Copeland, Amy R., Robbins, Paul F., Rosenberg, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448939/ https://www.ncbi.nlm.nih.gov/pubmed/34168045 http://dx.doi.org/10.1158/1078-0432.CCR-21-0849

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