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Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations

Identifying resistance mutations in a drug target provides crucial information. Lentiviral transduction creates multiple types of mutations due to the error-prone nature of the HIV-1 reverse transcriptase (RT). Here we optimized and leveraged this property to identify drug resistance mutations, deve...

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Detalles Bibliográficos
Autores principales:	Yenerall, Paul, Kollipara, Rahul K., Avila, Kimberley, Peyton, Michael, Eide, Christopher A., Bottomly, Daniel, McWeeney, Shannon K., Liu, Yan, Westover, Kenneth D., Druker, Brian J., Minna, John D., Kittler, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Resource Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448967/ https://www.ncbi.nlm.nih.gov/pubmed/34301758 http://dx.doi.org/10.1158/0008-5472.CAN-21-1153

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