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Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia

PURPOSE: Systems biology approaches can identify critical targets in complex cancer signaling networks to inform new therapy combinations that may overcome conventional treatment resistance. EXPERIMENTAL DESIGN: We performed integrated analysis of 1,046 childhood B-ALL cases and developed a data-dri...

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Detalles Bibliográficos
Autores principales:	Ding, Yang-Yang, Kim, Hannah, Madden, Kellyn, Loftus, Joseph P., Chen, Gregory M., Allen, David Hottman, Zhang, Ruitao, Xu, Jason, Chen, Chia-Hui, Hu, Yuxuan, Tasian, Sarah K., Tan, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448976/ https://www.ncbi.nlm.nih.gov/pubmed/34210682 http://dx.doi.org/10.1158/1078-0432.CCR-21-0553

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