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Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors

Robust assays to quantify adeno-associated virus (AAV) vector expression and potency are essential for gene therapy development. These assays inform the efficacy, safety, and pharmacodynamic profiles of AAV development candidates. Additionally, for gene downregulation strategies such as RNAi, knockd...

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Detalles Bibliográficos
Autores principales:	Clarner, Pete, Lau, Shukkwan K., Chowdhury, Twinkle, Guilmette, Edward, Trapa, Patrick, Lo, Shih-Ching, Shen, Shen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449018/ https://www.ncbi.nlm.nih.gov/pubmed/34589555 http://dx.doi.org/10.1016/j.omtm.2021.05.003

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