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Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics

BACKGROUND: Cognitive decline leading to dementia, accompanied by the accumulation of amyloid-beta (Aβ) in neuritic plaques together with the appearance of neurofibrillary tangles (NFT) composed of hyperphosphorylated tau protein (tau), are previously noted hallmarks of Alzheimer's disease (AD)...

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Detalles Bibliográficos
Autores principales:	Singh, Chaahat S.B., Choi, Kyung Bok, Munro, Lonna, Wang, Hong Yue, Pfeifer, Cheryl G., Jefferies, Wilfred A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449085/ https://www.ncbi.nlm.nih.gov/pubmed/34534764 http://dx.doi.org/10.1016/j.ebiom.2021.103503

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